Fumagillin | MetAP-2 inhibitor

CAS:
23110-15-8
Catalog Number:
10-1146
Activity:
MetAP-2 inhibitor
Chemical Name:
(2E,4E,6E,8E)-Mono[(3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-1-oxaspiro[2.5]oct-6-yl] 2,4,6,8-decatetraenedioic acid ester
Molecular Weight:
458.54
Molecular Formula:
C26H34>/sub>O7
Solubility:
Soluble in DMSO (up to 25 mg/ml).
Physical Properties:
Orange solid
Purity:
95% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Available Options

size :PriceQuantity 
1 mg$75.00
5 mg$290.00

Fumagillin (23110-15-8) is a natural product isolated from the microbial organism Aspergillus fumigatus and used as an antimicrobial for honey bees. It covalently binds and inhibits methionine aminopeptidase-2.1 Fumagillin also inhibits endothelial cell proliferation in vitro and tumor-induced angiogenesis in vivo.2

References/Citations:

1) Sin et al. (1997) The anti-angiogenic agent fumagillin covalently binds and inhibits the methionine aminopeptidase, MetAP-2; Proc. Natl. Acad. Sci. USA, 94 6099
2) Ingber et al. (1990) Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth; Nature, 348 555

CAS:
23110-15-8
Catalog Number:
10-1146
Activity:
MetAP-2 inhibitor
Chemical Name:
(2E,4E,6E,8E)-Mono[(3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-1-oxaspiro[2.5]oct-6-yl] 2,4,6,8-decatetraenedioic acid ester
Molecular Weight:
458.54
Molecular Formula:
C26H34>/sub>O7
Solubility:
Soluble in DMSO (up to 25 mg/ml).
Physical Properties:
Orange solid
Purity:
95% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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