Fumarate hydratase-IN-1 | Fumarate hydratase inhibitor
Available Options
| Size | Price | Quantity | |
|---|---|---|---|
| 5mg | $95.00 | ||
| 25mg | $350.00 |
Fumarate hydratase-IN-1 (1644060-37-6) is a pro-drug inhibitor of fumarate hydratase, an important enzyme in the tricarboxylic acid (TCA) cycle. This cell permeable compound is converted to the active carboxylic acid by intracellular esterases (Ki = 4.5 µM for free acid). The ethyl ester displayed cell-growth inhibitory activity against several cancer lines under nutrient (glucose) deprived conditions with an average IC50 = 2.2 µM.
References/Citations:
- Takeuchi et al. (2015), Identification of Fumarate Hydratase Inhibitors with Nutrient-Dependent Cytotoxicity; J. Am. Soc. Chem. 137 564
C27H30N2O4
>98% HPLC
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Fumarate hydratase-IN-1 (1644060-37-6) is a pro-drug inhibitor of fumarate hydratase, an important enzyme in the tricarboxylic acid (TCA) cycle. This cell permeable compound is converted to the active carboxylic acid by intracellular esterases (Ki = 4.5 µM for free acid). The ethyl ester displayed cell-growth inhibitory activity against several cancer lines under nutrient (glucose) deprived conditions with an average IC50 = 2.2 µM.
References/Citations:
- Takeuchi et al. (2015), Identification of Fumarate Hydratase Inhibitors with Nutrient-Dependent Cytotoxicity; J. Am. Soc. Chem. 137 564
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1-855-FOCUS21
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