gamma-L-Glutamyl-p-nitroanilide HCl | L-Glutamine uptake inhibitor and gamma-glutamyl transpeptidase substrate
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 100 mg | $20.00 | ||
| 250 mg | $30.00 |
L-γ-Glutamyl-p-nitroanilide (67953-08-6; GPNA) is a substrate for γ-glutamyl transpeptidase. GPNA is used for the determination of γ-glutamyl transpeptidase hydrolytic activity via spectrophotometric monitoring of p-nitroaniline released by the action of the enzyme on GPNA.1 GPNA has also been shown to be an inhibitor of glutamine uptake – solute-linked carrier family A1 member 5 (SLC1A5).2 Cellular uptake of L-glutamine (regulated by SLC1A5) is a rate-limiting step that activates mTOR and is, thus, an interesting cancer chemotherapy target.3
References/Citations:
1) Meister et al. (1981), γ-Glutamyl transpeptidase; Methods Enzymol., 77 237
2) Esslinger et al. (2005), N-gamma-aryl glutamine analogues as probes of the ASCT2 neutral amino acid transporter binding site; Bioorg. Med. Chem., 13 1111
3) Nicklin et al. (2012), Bidirectional Transport of Amino Acid Regulates mTOR and Autophagy; Cell, 136 521
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
L-γ-Glutamyl-p-nitroanilide (67953-08-6; GPNA) is a substrate for γ-glutamyl transpeptidase. GPNA is used for the determination of γ-glutamyl transpeptidase hydrolytic activity via spectrophotometric monitoring of p-nitroaniline released by the action of the enzyme on GPNA.1 GPNA has also been shown to be an inhibitor of glutamine uptake – solute-linked carrier family A1 member 5 (SLC1A5).2 Cellular uptake of L-glutamine (regulated by SLC1A5) is a rate-limiting step that activates mTOR and is, thus, an interesting cancer chemotherapy target.3
References/Citations:
1) Meister et al. (1981), γ-Glutamyl transpeptidase; Methods Enzymol., 77 237
2) Esslinger et al. (2005), N-gamma-aryl glutamine analogues as probes of the ASCT2 neutral amino acid transporter binding site; Bioorg. Med. Chem., 13 1111
3) Nicklin et al. (2012), Bidirectional Transport of Amino Acid Regulates mTOR and Autophagy; Cell, 136 521
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Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21
Focus Biomolecules
Plymouth Meeting, PA USA
1-855-FOCUS21
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