GBR-12909 2HCl | Dopamine reuptake inhibitor

CAS:
67469-78-7
Catalog Number:
10-1458
Activity:
Dopamine reuptake inhibitor
Chemical Name:
1-[2-[Bis-(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine dihydrochloride
Alternate Name:
Vanoxerine
Molecular Weight:
523.5
Molecular Formula:
C28H32F2N2O 2HCl
Solubility:
Soluble in DMSO (up to 30 mg/ml with warming) or in Water (up to 10 mg/ml with warming).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
Shipping Code:
RT

Available Options

Size :PriceQuantity 
10 mg$60.00
50 mg$240.00

GBR-12909 2HCl (67469-78-7) is a potent and selective inhibitor of dopamine reuptake (Ki = 1 nM) with greater than 100 fold selectivity over serotonin and noradrenaline.1 GBR-12909 2HCl also acts as a potent sigma receptor ligand.2 Very fast acting via i.v. administration.3

References/Citations:

1) Andersen et al. (1989), The dopamine inhibitor GBR 12909: selectivity and molecular mechanism of action; Eur. J. Pharmacol., 166 493
2) Contreras et al. (1990), GBR-12909 and fluspirilene potently inhibited binding of [3H] (+)3-PPP to sigma receptors in rat brain; Life Sci., 47 PL133
3) Yorgason et al. (2011), Low and high affinity dopamine transporter inhibitors block dopamine uptake within 5 sec of intravenous injection; Neuroscience, 182 125

CAS:
67469-78-7
Catalog Number:
10-1458
Activity:
Dopamine reuptake inhibitor
Chemical Name:
1-[2-[Bis-(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine dihydrochloride
Alternate Name:
Vanoxerine
Molecular Weight:
523.5
Molecular Formula:
C28H32F2N2O 2HCl
Solubility:
Soluble in DMSO (up to 30 mg/ml with warming) or in Water (up to 10 mg/ml with warming).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
Shipping Code:
RT

Safety Data Sheet:

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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