Gefitinib | EGFR kinase inhibitor
NMR (Conforms)
Available Options
| size : | Price | Quantity | |
|---|---|---|---|
| 50 mg | $30.00 | ||
| 250 mg | $66.00 |
Gefitinib (184475-35-2) is a potent and selective EGFR kinase inhibitor (IC50 = 23-79 nM).1 Inhibits EGFR autophosphorylation and inhibits tumor growth in vivo.2 Enhances efficacy of cytotoxic agents.3 Inhibits growth factor production and angiogenesis.4 Clinically useful anticancer agent.
References/Citations:
1) Baselga et al. (2000), ZD1839 (‘Iressa’) as an anticancer agent; Drugs, 60 33
2) McKillop et al. (2005), Tumor penetration of gefitinib (Iressa), an epidermal growth factor receptor tyrosine kinase inhibitor; Mol. Cancer Ther., 4 641
3) Sirotnak et al. (2000), Efficacy of cytotoxic agents against human tumor xenografts is markedly enhanced by coadministration of ZD1839 (Iressa), an inhibitor of EGFR tyrosine kinase; Clin. Cancer Res., 6 4885
4) Ciaradiello et al. (2001), Inhibition of growth factor production and angiogenesis in human cancer cells by ZD1839 (Iressa), a selective epidermal growth factor receptor tyrosine kinase inhibitor; Clin. Cancer Res., 7 1459
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
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Gefitinib (184475-35-2) is a potent and selective EGFR kinase inhibitor (IC50 = 23-79 nM).1 Inhibits EGFR autophosphorylation and inhibits tumor growth in vivo.2 Enhances efficacy of cytotoxic agents.3 Inhibits growth factor production and angiogenesis.4 Clinically useful anticancer agent.
References/Citations:
1) Baselga et al. (2000), ZD1839 (‘Iressa’) as an anticancer agent; Drugs, 60 33
2) McKillop et al. (2005), Tumor penetration of gefitinib (Iressa), an epidermal growth factor receptor tyrosine kinase inhibitor; Mol. Cancer Ther., 4 641
3) Sirotnak et al. (2000), Efficacy of cytotoxic agents against human tumor xenografts is markedly enhanced by coadministration of ZD1839 (Iressa), an inhibitor of EGFR tyrosine kinase; Clin. Cancer Res., 6 4885
4) Ciaradiello et al. (2001), Inhibition of growth factor production and angiogenesis in human cancer cells by ZD1839 (Iressa), a selective epidermal growth factor receptor tyrosine kinase inhibitor; Clin. Cancer Res., 7 1459
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