Geldanamycin-FITC | HSP90 fluorescent probe
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 5 mg | $600.00 | ||
| 1 mg | $200.00 |
Geldanamycin-FITC is a novel geldanamycin fluorescent probe1 that may be used in a fluorescence polarization assay for HSP-90 inhibitors.2,3 May also be used for detection of cell surface HSP-90 and for other applications. Fluorescent geldanamycin probes have been used to characterize geldanamycin drug-target interactions for effective translation of in vitro pharmacology to cellular and in vivo efficacy.4
References/Citations:
1) Llauger-Bufi et al. (2003), Synthesis of novel fluorescent probes for the molecular chaperone Hsp90; Bioorg. Med. Chem. Lett., 13 3975
2) Kim et al. (2004), Development of a fluorescent polarization assay for the molecular chaperone Hsp90; J. Biomol. Screen., 9 375
3) Austin et al. (2012), Fragment screening using capillary electrophoresis (Defrag) for hit identification of heat shock protein 90 ATPase inhibitors; J. Biomol. Screen., 17 868
4) Gooljarsingh et al. (2006), A biochemical rationale for the anticancer effects of Hsp90 inhibitors: slow, tight binding inhibition by geldanamycin and its analogues; Proc. Natl. Acad. Sci. USA, 103 7625
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Geldanamycin-FITC is a novel geldanamycin fluorescent probe1 that may be used in a fluorescence polarization assay for HSP-90 inhibitors.2,3 May also be used for detection of cell surface HSP-90 and for other applications. Fluorescent geldanamycin probes have been used to characterize geldanamycin drug-target interactions for effective translation of in vitro pharmacology to cellular and in vivo efficacy.4
References/Citations:
1) Llauger-Bufi et al. (2003), Synthesis of novel fluorescent probes for the molecular chaperone Hsp90; Bioorg. Med. Chem. Lett., 13 3975
2) Kim et al. (2004), Development of a fluorescent polarization assay for the molecular chaperone Hsp90; J. Biomol. Screen., 9 375
3) Austin et al. (2012), Fragment screening using capillary electrophoresis (Defrag) for hit identification of heat shock protein 90 ATPase inhibitors; J. Biomol. Screen., 17 868
4) Gooljarsingh et al. (2006), A biochemical rationale for the anticancer effects of Hsp90 inhibitors: slow, tight binding inhibition by geldanamycin and its analogues; Proc. Natl. Acad. Sci. USA, 103 7625
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