Geldanamycin | HSP90 inhibitor

CAS:
30562-34-6
Catalog Number:
10-1084
Activity:
HSP90 inhibitor
Alternate Names:
NSC 122750; U-29135
Chemical Name:
9,13-Dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione,9-carbamate
Molecular Weight:
560.65
Molecular Formula:
C29H40N2O9
Solubility:
Soluble in DMSO (up to 50 mg/ml).
Physical Properties:
Yellow solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months
Shipping Code:
RT

Available Options

size :PriceQuantity 
1 mg$50.00
5 mg$100.00

Geldanamycin (30562-34-6) inhibits HSP90 by binding to its ATP-binding domain (Kd=1.2 μM) and subsequently inhibits HSP90 client proteins. Geldanamycin induces apoptosis in various cell types. Cell permeable.

References/Citations:

1) Neckers et al. (1999), Geldanamycin as a potential anti-cancer agent: its molecular target and biochemical activity; Invest. New Drugs, 17 361
2) Zang et al. (2006), HSP90 protects apoptotic cleavage of vimentin in geldanamycin-induced apoptosis; Mol. Cell. Biochem., 281 111

CAS:
30562-34-6
Catalog Number:
10-1084
Activity:
HSP90 inhibitor
Alternate Names:
NSC 122750; U-29135
Chemical Name:
9,13-Dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione,9-carbamate
Molecular Weight:
560.65
Molecular Formula:
C29H40N2O9
Solubility:
Soluble in DMSO (up to 50 mg/ml).
Physical Properties:
Yellow solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months
Shipping Code:
RT

Safety Data Sheet:

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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