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Gemcitabine HCl | DNA polymerase inhibitor

Gemcitabine HCl (122111-03-9) is a clinically useful anticancer agent.1 It exerts its cytotoxic effects via the metabolites gemcitabine diphosphate (dFdCDP) and gemcitabine triphosphate (dFdCTP). dFdCTP is an inhibitor of DNA polymerase and is also incorporated in DNA strands resulting in termination of chain elongation and apoptosis. dFdCDP is an inhibitor of ribonucleotide reductase which results in depletion of deoxyribonucleotides needed for DNA synthesis. Gemcitabine metabolites have also been reported to inhibit cytidine triphosphate synthetase (CTP synthetase)2 and deoxycytidylate deaminase (dCMP deaminase)3. Topoisomerase 1 has also been shown to be a target for gemcitabine.4

1) Mini et al. (2006), Cellular Pharmacology of Gemcitabine; Ann. Oncol. 17 v7
2) Heinemann et al. (1995), Gemcitabine: a modulator of intracellular nucleotide and deoxynucleotide metabolism; Semin. Oncol. 22 11
3) Heinemann et al. (1992), Cellular elimination of 2',2'-difluorodeoxycytidine 5'triphosphate: a mechanism of self-potentiation; Cancer Res. 52 533
4) Pourquier et al. (2002), Gemcitabine (2',2'-difluoro-2'-deoxycytidine), an antimetabolite that poisons topoisomerase I; Clin.Cancer Res. 8 2499

Focus Biomolecules supplier, chemical structure of Gemcitabine HCl | DNA polymerase inhibitor | CAS 122111-03-9

Catalog#  10-2140

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Catalog Number:
DNA polymerase inhibitor
Alternate Names:
Chemical Name:
2'-Deoxy-2',2'-difluorocytidine hydrochloride
Molecular Weight:
Molecular Formula:
C9H11F2N3O4 HCl
Soluble in DMSO (up to 20 mg/ml) or in Water (up to 25 mg/ml).
Physical Properties:
White solid
Storage Temperature:
Stable for 1 year as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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