ISRIB | Integrated stress response inhibitor
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 5 mg | $60.00 | ||
| 25 mg | $240.00 |
ISRIB (1597403-47-8) is an integrated stress response inhibitor. Potently reverses the effects of initiation factor 2α (eIF2α) phosphorylation, IC50=5 nM.1 Enhances spatial and fear-associated learning in mice and enhances cognitive function.1,2 Mechanism of action involves activation of eiF2β.3 Suppresses ER stress-induced inflammatory gene expression.4 Potently attenuates amyloid β-induced neuronal cell death (12.5-25 nM) with no effect on amyloid β production.5 Reverses hippocampal-dependent cognitive deficits induced by traumatic brain injury in two different injury mouse models.6
References/Citations:
1) Sidrauski et al. (2013), Pharmacological brake-release of mRNA translation enhances cognitive memory; Elife, 2 e00498
2) Sekine et al. (2015), Stress responses. Mutations in a translation initiation factor identify the target of a memory-enhancing compound; Science, 348 1027
3) Sidrauski et al. (2015), Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response; Elife, 4 e07314
4) Guthrie et al. (2016), Attenuation of PKR-like ER Kinase (PERK) Signaling Selectively Controls Endoplasmic Reticulum Stress-Induced Inflammation Without Compromising Immunological Responses; J. Biol. Chem., 291 15830
5) Hosoi et al. (2016), Unique pharmacological property of ISRIB in inhibition of Aβ-induced neuronal cell death; J. Pharmacol. Sci., 131 292
6) Chou et al. (2017), Inhibition of the integrated stress response reverses cognitive deficits after traumatic brain injury; Proc. Natl. Acad. Sci. USA, 114 E6420
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
ISRIB (1597403-47-8) is an integrated stress response inhibitor. Potently reverses the effects of initiation factor 2α (eIF2α) phosphorylation, IC50=5 nM.1 Enhances spatial and fear-associated learning in mice and enhances cognitive function.1,2 Mechanism of action involves activation of eiF2β.3 Suppresses ER stress-induced inflammatory gene expression.4 Potently attenuates amyloid β-induced neuronal cell death (12.5-25 nM) with no effect on amyloid β production.5 Reverses hippocampal-dependent cognitive deficits induced by traumatic brain injury in two different injury mouse models.6
References/Citations:
1) Sidrauski et al. (2013), Pharmacological brake-release of mRNA translation enhances cognitive memory; Elife, 2 e00498
2) Sekine et al. (2015), Stress responses. Mutations in a translation initiation factor identify the target of a memory-enhancing compound; Science, 348 1027
3) Sidrauski et al. (2015), Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response; Elife, 4 e07314
4) Guthrie et al. (2016), Attenuation of PKR-like ER Kinase (PERK) Signaling Selectively Controls Endoplasmic Reticulum Stress-Induced Inflammation Without Compromising Immunological Responses; J. Biol. Chem., 291 15830
5) Hosoi et al. (2016), Unique pharmacological property of ISRIB in inhibition of Aβ-induced neuronal cell death; J. Pharmacol. Sci., 131 292
6) Chou et al. (2017), Inhibition of the integrated stress response reverses cognitive deficits after traumatic brain injury; Proc. Natl. Acad. Sci. USA, 114 E6420
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