GFB-8438 | Selective TRPC5 inhibitor
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $60.00 | ||
| 25 mg | $225.00 |
GFB-8438 (2304549-73-1) is a potent (IC50 = 180 nM Qpatch and 280 nM whole cells) and selective inhibitor of TRPC4 and 5.1 It displayed excellent selectivity against other TRP family members as well as NaV1.5, 50 kinases and 87 other receptor targets along with good pharmacokinetic properties. GFB-8438 protected mouse podocytes from injury induced by protamine sulfate and demonstrated efficacy in a hypertensive DOCA-salt rat model suggesting potential therapeutic use for the treatment of chronic kidney disease.
References/Citations:
- Yu et al. (2019), Discovery of a Potent and Selective TRPC5 Inhibitor, Efficacious in a Focal Segmental Glomerulosclerosis Model; ACS Med. Chem. Lett. 10 1579
C16H14ClF3N4O2
>98% by HPLC
NMR: (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
GFB-8438 (2304549-73-1) is a potent (IC50 = 180 nM Qpatch and 280 nM whole cells) and selective inhibitor of TRPC4 and 5.1 It displayed excellent selectivity against other TRP family members as well as NaV1.5, 50 kinases and 87 other receptor targets along with good pharmacokinetic properties. GFB-8438 protected mouse podocytes from injury induced by protamine sulfate and demonstrated efficacy in a hypertensive DOCA-salt rat model suggesting potential therapeutic use for the treatment of chronic kidney disease.
References/Citations:
- Yu et al. (2019), Discovery of a Potent and Selective TRPC5 Inhibitor, Efficacious in a Focal Segmental Glomerulosclerosis Model; ACS Med. Chem. Lett. 10 1579
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