Gilteritinib | FLT3 Inhibitor

CAS:
1254053-43-4
Catalog Number:
10-4170
Activity:
FLT3 inhibitor
Chemical Names:
6-Ethyl-3-[3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]anilino]-5-(oxan-4-ylamino)pyrazine-2-carboxamide; ASP2215
Molecular Weight:
552.72
Molecular Formula:
C29H44N8O3
Solubility:
Soluble in DMSO (25 mg/ml)
Physical Properties:
Off-white to pale pink solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Available Options

Size:PriceQuantity 
5 mg$45.00
25 mg$165.00

Gilteritinib (1254053-43-4) is a potent inhibitor of FLT3 (IC50 = 5 nM, wild-type FLT3) with more potent activity against all FLT3 mutants.1 It also potently inhibits Axl (IC50 = 41 nM). Clinically useful in the treatment of acute myeloid leukemia. Gilteritinib has also been shown to inhibit glutamine uptake and utilization via downregulation of glutamine transporters.2

References:

  1. Lee et al. (2017) Preclinical studies of gilteritinib, a next-generation FLT3 inhibitor; Blood 129 257
  2. Thomas et al. (2021) Gilteritinib Inhibits Glutamine Uptake and Utilization in FLT-3-ITD-Positive AML; Cancer Ther. 20 2207
CAS:
1254053-43-4
Catalog Number:
10-4170
Activity:
FLT3 inhibitor
Chemical Names:
6-Ethyl-3-[3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]anilino]-5-(oxan-4-ylamino)pyrazine-2-carboxamide; ASP2215
Molecular Weight:
552.72
Molecular Formula:
C29H44N8O3
Solubility:
Soluble in DMSO (25 mg/ml)
Physical Properties:
Off-white to pale pink solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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