Gilteritinib | FLT3 Inhibitor
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $45.00 | ||
| 25 mg | $165.00 |
Gilteritinib (1254053-43-4) is a potent inhibitor of FLT3 (IC50 = 5 nM, wild-type FLT3) with more potent activity against all FLT3 mutants.1 It also potently inhibits Axl (IC50 = 41 nM). Clinically useful in the treatment of acute myeloid leukemia. Gilteritinib has also been shown to inhibit glutamine uptake and utilization via downregulation of glutamine transporters.2
References:
- Lee et al. (2017) Preclinical studies of gilteritinib, a next-generation FLT3 inhibitor; Blood 129 257
- Thomas et al. (2021) Gilteritinib Inhibits Glutamine Uptake and Utilization in FLT-3-ITD-Positive AML; Cancer Ther. 20 2207
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
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Gilteritinib (1254053-43-4) is a potent inhibitor of FLT3 (IC50 = 5 nM, wild-type FLT3) with more potent activity against all FLT3 mutants.1 It also potently inhibits Axl (IC50 = 41 nM). Clinically useful in the treatment of acute myeloid leukemia. Gilteritinib has also been shown to inhibit glutamine uptake and utilization via downregulation of glutamine transporters.2
References:
- Lee et al. (2017) Preclinical studies of gilteritinib, a next-generation FLT3 inhibitor; Blood 129 257
- Thomas et al. (2021) Gilteritinib Inhibits Glutamine Uptake and Utilization in FLT-3-ITD-Positive AML; Cancer Ther. 20 2207
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