Ginkgolide B | PAF receptor antagonist
NMR (Conforms)
Available Options
| size : | Price | Quantity | |
|---|---|---|---|
| 10mg | $40.00 | ||
| 50mg | $160.00 |
Ginkgolide B (15291-77-7) is a PAF receptor antagonist (Ki = 1.3 μM)1. Inhibits neutrophil degranulation and superoxide production in vitro1. Inhibits PAF-induced bronchoconstriction in a guinea pig model.2 Ginkgolide B also displays neuroprotective effects in various models.3,4 Protects against focal cerebral ischemia via inhibition of the mitochondrial apoptotic pathway.5
References/Citations:
1) Foldes-Filep et al. (1987), Inhibition by BN 52021 (ginkgolide B) of the binding of [3H]-platelet-activating factor to human neutrophil granulocytes; Biochem. Biophys. Res. Commun., 148 1412
2) Desquand et al. (1986), Interference of BN 52021 (ginkgolide B) with the bronchopulmonary effects of PAF-acether in the guinea-pig; Eur. J. Pharmacol., 127 83
3) Maclennan et al. (2002), The CNS effects of Ginko biloba extracts and ginkgolide B; Prog. Neurobiol., 67 235
4) Li et al. (2013), Neuroprotective effect of ginkogolide B on bupivacaine-induced apoptosis in SH-SY5Y cells; Oxid. Med. Cell. Longev., 2013 159864
5) Wang et al. (2014), Neuroprotection against permanent focal cerebral ischemia by ginkgolides A and B is associated with obstruction of the mitochondrial apoptotic pathway via inhibition of c-Jun N-terminal kinase in rats; J. Neurosci. Res., 92 232
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Ginkgolide B (15291-77-7) is a PAF receptor antagonist (Ki = 1.3 μM)1. Inhibits neutrophil degranulation and superoxide production in vitro1. Inhibits PAF-induced bronchoconstriction in a guinea pig model.2 Ginkgolide B also displays neuroprotective effects in various models.3,4 Protects against focal cerebral ischemia via inhibition of the mitochondrial apoptotic pathway.5
References/Citations:
1) Foldes-Filep et al. (1987), Inhibition by BN 52021 (ginkgolide B) of the binding of [3H]-platelet-activating factor to human neutrophil granulocytes; Biochem. Biophys. Res. Commun., 148 1412
2) Desquand et al. (1986), Interference of BN 52021 (ginkgolide B) with the bronchopulmonary effects of PAF-acether in the guinea-pig; Eur. J. Pharmacol., 127 83
3) Maclennan et al. (2002), The CNS effects of Ginko biloba extracts and ginkgolide B; Prog. Neurobiol., 67 235
4) Li et al. (2013), Neuroprotective effect of ginkogolide B on bupivacaine-induced apoptosis in SH-SY5Y cells; Oxid. Med. Cell. Longev., 2013 159864
5) Wang et al. (2014), Neuroprotection against permanent focal cerebral ischemia by ginkgolides A and B is associated with obstruction of the mitochondrial apoptotic pathway via inhibition of c-Jun N-terminal kinase in rats; J. Neurosci. Res., 92 232
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