Glumetinib | Highly selective c-Met inhibitor

CAS:
1642581-63-2
Catalog Number:
10-4690
Activity:
Highly selective c-Met inhibitor
Chemical Names:
6-(1-Methylpyrazol-4-yl)-1-[6-(1-methylpyrazol-4-yl)imidazo[1,2-a]pyridine-3-yl]sulfonylpyrazolo[4,3-b]pyridine: SCC244
Molecular Weight:
459.48
Molecular Formula:
C21H17N9O2S
Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
Beige solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Available Options

Size:PriceQuantity 
5 mg$90.00
25 mg$325.00

Glumetinib (1642581-63-2) is a highly selective (2400-fold selectivity against a panel of 312 kinases) and potent (IC50 = 0.42 nM) inhibitor of c-Met kinase.  It induced tumor regression in MET-driven CDX (MKN-45, SNU-5, EBC-1) and PDX (4 NSCLC, 5 HCC) tumor models.

References/Citations:

  1. Ai et al. (2018), Preclinical Evaluation of SCC244 (Glumetinib), a Novel, Potent, and Highly Selective Inhibitor of c-Met in MET-dependent Cancer Models; Cancer Res., 17 751
CAS:
1642581-63-2
Catalog Number:
10-4690
Activity:
Highly selective c-Met inhibitor
Chemical Names:
6-(1-Methylpyrazol-4-yl)-1-[6-(1-methylpyrazol-4-yl)imidazo[1,2-a]pyridine-3-yl]sulfonylpyrazolo[4,3-b]pyridine: SCC244
Molecular Weight:
459.48
Molecular Formula:
C21H17N9O2S
Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
Beige solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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