GO289 | CK2 inhibitor

CAS:
694522-87-7
Catalog Number:
10-4678
Activity:
CK2 inhibitor
Chemical Names:
(E)-5-Bromo-2-methoxy-4-(((3-(methylthio)-5-phenyl-4H-1,2,4-4-yl)imino)methyl)phenol
Molecular Weight:
419.30
Molecular Formula:
C17H15BrN4O2S
Solubility:
Soluble in DMSO (25 mg/ml)
Physical Properties:
Off-white solid
Purity:
98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Available Options

Size:PriceQuantity 
5 mg$95.00
25 mg$350.00

GO289 (694522-87-7) is a potent inhibitor of casein kinase 2 (CK2; IC50 = 7 nM).1 Showed no inhibition of DYRK, HIPK, CLK, and PIM family kinases.  It is a circadian clock modifier that caused strong period lengthening. Growth of MLL-AF9 leukemia cells was strongly inhibited by GO289.

References/Citations:

  1. Oshima et al. (2019), Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth; Sci. Adv. 5 eauu9060
CAS:
694522-87-7
Catalog Number:
10-4678
Activity:
CK2 inhibitor
Chemical Names:
(E)-5-Bromo-2-methoxy-4-(((3-(methylthio)-5-phenyl-4H-1,2,4-4-yl)imino)methyl)phenol
Molecular Weight:
419.30
Molecular Formula:
C17H15BrN4O2S
Solubility:
Soluble in DMSO (25 mg/ml)
Physical Properties:
Off-white solid
Purity:
98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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