GRI-977143 | LPA2 antagonist
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 5 mg | $80.00 | ||
| 25 mg | $320.00 |
GRI-977143 (325850-81-5) is a selective agonist of the lysophosphatidic acid-2 (LPA2) receptor. Displays antiapoptotic activity.1 Rescues apoptotically condemned cells from death and injury caused by high-dose γ-irradiation in vitro and in vivo. GRI-977143 rescues mice from deadly levels of radiation when given 24 hours post-exposure.2 Activates the ERK1/2 prosurvival pathway.2
References/Citations:
1) Kiss et al. (2012), Virtual screening for LPA2-specific agonists identifies a nonlipid compound with antiapoptotic actions; Mol. Pharmacol. 82 1162
2) Kiss et al. (2013), Mitigation of radiation injury by selective stimulation of the LPA2 receptor; Biochim. Biophys. Acta 1831 117
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
GRI-977143 (325850-81-5) is a selective agonist of the lysophosphatidic acid-2 (LPA2) receptor. Displays antiapoptotic activity.1 Rescues apoptotically condemned cells from death and injury caused by high-dose γ-irradiation in vitro and in vivo. GRI-977143 rescues mice from deadly levels of radiation when given 24 hours post-exposure.2 Activates the ERK1/2 prosurvival pathway.2
References/Citations:
1) Kiss et al. (2012), Virtual screening for LPA2-specific agonists identifies a nonlipid compound with antiapoptotic actions; Mol. Pharmacol. 82 1162
2) Kiss et al. (2013), Mitigation of radiation injury by selective stimulation of the LPA2 receptor; Biochim. Biophys. Acta 1831 117
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