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Griseofulvin | Inhibitor of centrosomal clustering

Griseofulvin (126-07-8) is an antifungal antimitotic agent. Induces apoptosis of human germ cell tumor cells via disruption of connexin 43/tubulin association concomitant with enhanced translocation of connexin 43 from the cytoplasm to the nucleus1. Inhibits the growth of adrenocortical cancer cells in vitro2. Griseofulvin inhibits centrosome clustering, induces spindle multipolarity, mitotic arrest and cell death in multiple tumor cell lines but not in diploid fibroblasts and keratinocytes with normal centrosome content3.

References/Citations
1) Mauro et al. (2013), The anti-mitotic drug griseofulvin induces apoptosis of human germ cell tumor cells through a connexin 43-dependent molecular mechanism; Apoptosis, 18 480
2) Bramann et al. (2013), Griseofulvin inhibits the growth of adrenocortical cancer cells in vitro; Horm. Metab. Res., 45 297
3) Rebacz et al. (2007), Identification of griseofulvin as an inhibitor of centrosomal clustering in a phenotype-based screen; Cancer Res., 67 6342

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Catalog#  10-2745

$45.00
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CAS:
126-07-8
Catalog Number:
10-2745
Activity:
Inhibitor of centrosomal clustering
Chemical Name:
Fermentation product from Penicili>ium sp.
Molecular Weight:
352.77
Molecular Formula:
C17H17ClO6
Solubility:
Soluble in DMSO (up to 40 mg/ml), in DMF (up to 50 mg/ml), or in Ethanol (up to 5 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year as supplied. Solutions in DMSO, ethanol, or DMF may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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