GRL-0617 | Potent SARS-CoV PLpro inhibitor

CAS:
1093070-16-6
Catalog Number:
10-4965
Activity:
Potent SARS-CoV PLpro inhibitor
Chemical Name:
5-Amino-2-methyl-N-(1R-naphthalen-1-yl-ethyl)benzamide
Molecular Weight:
304.39
Molecular Formula:
C20H20N2O
Solubility:
Soluble in DMSO (>30 mg/mL) and ethanol (15 mg/mL)
Physical Properties:
Beige solid
Purity:
99% by HPLC
NMR (Conforms)
Storage Temperature:
-20° (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT

Available Options

Size:PriceQuantity 
5 mg$75.00
25 mg$250.00

GRL-0617 (1093070-16-6) is a potent (IC50 = 600 nM) noncovalent inhibitor of severe acute respiratory syndrome-coronavirus papain-like protease (SARS-CoV PLpro). GRL-0617 inhibited SARS-CoV viral replication in Vero E6 cells with no cytotoxicity (EC50 = 15 µM).  Inactive against human DUB-like proteases HAUSP, USP18, UCH-L1, UCH-L3, and PLP2

References/Citations

1)    Ratia et al. (2008), A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication; Proc. Natl. Acad. Sci. USA, 105 16119

2)    Ghosh et al. (2009), Structure-Based Design, Synthesis, and Biological Evaluation of a Series of Novel and Reversible Inhibitors for the Severe Acute Respiratory Syndrome-Coronavirus Papain-Like Protease; J. Med. Chem. 52 5228

CAS:
1093070-16-6
Catalog Number:
10-4965
Activity:
Potent SARS-CoV PLpro inhibitor
Chemical Name:
5-Amino-2-methyl-N-(1R-naphthalen-1-yl-ethyl)benzamide
Molecular Weight:
304.39
Molecular Formula:
C20H20N2O
Solubility:
Soluble in DMSO (>30 mg/mL) and ethanol (15 mg/mL)
Physical Properties:
Beige solid
Purity:
99% by HPLC
NMR (Conforms)
Storage Temperature:
-20° (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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