Triptolide | Immunosuppressant
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 1 mg | $35.00 | ||
| 5 mg | $95.00 |
Triptolide (38748-32-2) possesses potent immunosuppressive and anti-inflammatory activity. Irreversibly inhibits eukaryotic transcription via covalent binding to XPB, a subunit of the transcription factor TFIIH.1 Blocks transactivation of NFkB.2 Exhibits potent antiproliferative activity in 60 cancer cell lines (average IC50 = 12 nM) and synergizes with other anticancer agents.3 Inhibits the inflammatory response and remarkably decreases production of TNF-a, IL-1b and IL-6 in a rat model of rheumatoid arthritis.4
References/Citations:
1) He et al. (2015), Covalent Modification of a Cysteine Residue in the XPB Subunit of the General Transcription Factor TFIIH Through Single Epoxide Cleavage of the Transcription Inhibitor Triptolide; Angew. Chem. Int. Ed. Eng. 54 1859
2) Lee et al. (1999), PG490 (Triptolide) Cooperates with Tumor Necrosis factor-α to Induce Apoptosis in Tumor Cells; J. Biol. Chem, 274 13451
3) Qiao et al. (2016), Synergistic antitumor activity of gemcitabine combined with triptolide in pancreatic cancer cells; Oncol. Lett., 11 3527
4) Fan et al. (2016), Triptolide Modulates TREM-1 Signal Pathway to Inhibit the Inflammatory Response in Rheumatoid Arthritis; Int. J. Mol. Sci. 17 498
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Triptolide (38748-32-2) possesses potent immunosuppressive and anti-inflammatory activity. Irreversibly inhibits eukaryotic transcription via covalent binding to XPB, a subunit of the transcription factor TFIIH.1 Blocks transactivation of NFkB.2 Exhibits potent antiproliferative activity in 60 cancer cell lines (average IC50 = 12 nM) and synergizes with other anticancer agents.3 Inhibits the inflammatory response and remarkably decreases production of TNF-a, IL-1b and IL-6 in a rat model of rheumatoid arthritis.4
References/Citations:
1) He et al. (2015), Covalent Modification of a Cysteine Residue in the XPB Subunit of the General Transcription Factor TFIIH Through Single Epoxide Cleavage of the Transcription Inhibitor Triptolide; Angew. Chem. Int. Ed. Eng. 54 1859
2) Lee et al. (1999), PG490 (Triptolide) Cooperates with Tumor Necrosis factor-α to Induce Apoptosis in Tumor Cells; J. Biol. Chem, 274 13451
3) Qiao et al. (2016), Synergistic antitumor activity of gemcitabine combined with triptolide in pancreatic cancer cells; Oncol. Lett., 11 3527
4) Fan et al. (2016), Triptolide Modulates TREM-1 Signal Pathway to Inhibit the Inflammatory Response in Rheumatoid Arthritis; Int. J. Mol. Sci. 17 498
Related products
-
LFM-A13 | BTK inhibitor
From $55.00CAS:244240-24-2Catalog Number:10-1032Activity:BTK inhibitorChemical Name:(2Z)-2-Cyano-N-(2,5-dibromophenyl)-3-hydroxy-2-butenamideMolecular Weight:360Molecular Formula:C11H8Br2N2O2Solubility:Soluble in DMSO (up to 15 mg/ml) or in Ethanol (up to 15 mg/ml).Physical Properties:White solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 2 years from date of purchase as supplied. PROTECT FROM MOISTURE. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.Shipping Code:RT -
SU-4312 | VEGFR / PDGFR kinase inhibitor
From $70.00CAS:5812-07-7Catalog Number:10-1027Activity:VEGFR / PDGFR kinase inhibitorChemical Name:3-(4-Dimethylaminobenzylidene)-1,3-dihydroindol-2-oneMolecular Weight:264.33Molecular Formula:C 17H 16N 2OSolubility:Soluble in DMSO (up to 25 mg/ml).Physical Properties:Orange solidPurity:98% by TLC NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.Shipping Code:RT -
Ko-143 | BCRP inhibitor
From $110.00CAS:461054-93-3Catalog Number:10-1074Activity:BCRP inhibitorChemical Name:(3S,6S,12aS)-1,2,3,4,6,7,12,12a-Octahydro-9-methoxy-6-(2-methylpropyl)-1,4-dioxopyrazino[1′,2′:1,6]pyrido [3,4-b]indole-3-propanoic acid 1,1-dimethylethyl esterMolecular Weight:469.59Molecular Formula:C26H35N3O5Solubility:Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 50 mg/ml).Physical Properties:White solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 2 years from date of purchase as supplied. Protect from exposure to moisture. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.Shipping Code:RT
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21
Focus Biomolecules
Plymouth Meeting, PA USA
1-855-FOCUS21
Website Created by Advanta Advertising LLC.