GSK1702934A | TRPC 3/6 activator
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 10 mg | $110.00 | ||
| 50 mg | $440.00 |
GSK1702934A (924377-85-5) is a TRPC3 activator. In whole-cell patch-clamp experiments in HEK293 cells transduced with recombinant human TRPC3 or TRPC6, GSK-1702934A activated the TRPC3 and TRPC6 current with EC50 of 0.08 mM and 0.44 mM respectively. In the rat cardiomyocyte-like cell line H9C2 GSK-1702934A (1mM) activated TRPC6-like current and was completely blocked by GSK-417651A. It transiently increased the perfusion pressure of isolated rat heart retrogradely perfused via aortic cannulation at 1mM.1 Induces pro-arrhythmic and inotropic effects in TRPC3-overexpressing monocytes.2
References/Citations:
1) Xu et al. (2013) Characterization of Small Molecule TRPC3 and TRPC6 Agonists and Antagonists; Proceedings of the Biophysical Soc., 104(2) 454a
2) Doleschal et al. (2015) TRPC3 contributes to regulation of cardiac contractility and arrhythmogenesis by dynamic interaction with NCX1.; Cardiovasc. Res., 106 163
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
GSK1702934A (924377-85-5) is a TRPC3 activator. In whole-cell patch-clamp experiments in HEK293 cells transduced with recombinant human TRPC3 or TRPC6, GSK-1702934A activated the TRPC3 and TRPC6 current with EC50 of 0.08 mM and 0.44 mM respectively. In the rat cardiomyocyte-like cell line H9C2 GSK-1702934A (1mM) activated TRPC6-like current and was completely blocked by GSK-417651A. It transiently increased the perfusion pressure of isolated rat heart retrogradely perfused via aortic cannulation at 1mM.1 Induces pro-arrhythmic and inotropic effects in TRPC3-overexpressing monocytes.2
References/Citations:
1) Xu et al. (2013) Characterization of Small Molecule TRPC3 and TRPC6 Agonists and Antagonists; Proceedings of the Biophysical Soc., 104(2) 454a
2) Doleschal et al. (2015) TRPC3 contributes to regulation of cardiac contractility and arrhythmogenesis by dynamic interaction with NCX1.; Cardiovasc. Res., 106 163
Related products
-
Minoxidil | KATP channel opener
From $50.00CAS:38304-91-5Catalog Number:10-1214Activity:KATP channel openerChemical Name:6-Piperidine-1-ylpyrimidine-2,4-diamine 3-oxideMolecular Weight:209.25Molecular Formula:C9H15N5OSolubility:Soluble in DMSO (up to 5 mg/ml) or in Ethanol (up to 5 mg/ml).Physical Properties:White solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 2 years from date of purchase as supplied. Protect from moisture. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.Shipping Code:RT -
Polygodial | TRPA1 activator
From $60.00CAS:6754-20-7Catalog Number:10-1145Activity:TRPA1 activatorChemical Name:(1R,4aS,8aS)-5,5,8a-Trimethyl-1,4,4a,6,7,8-hexahydronaphthalene-1,2-dicarboxaldehydeMolecular Weight:234.34Molecular Formula:C15H22O2Solubility:Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).Physical Properties:Tan waxy solidPurity:97% by TLC
NMR (Conforms)Storage Temperature:-20°C (des.)Stability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.Shipping Code:RT -
2-APB | TRP channel blocker
From $25.00CAS:524-95-8Catalog Number:10-1212Activity:TRP activatorChemical Name:2-Aminoethoxydiphenyl borateMolecular Weight:225.1Molecular Formula:C14H16BNOSolubility:Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 5 mg/ml).Physical Properties:White solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.Shipping Code:RT
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
