GSK1702934A | TRPC 3/6 activator
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 10 mg | $110.00 | ||
| 50 mg | $440.00 |
GSK1702934A (924377-85-5) is a TRPC3 activator. In whole-cell patch-clamp experiments in HEK293 cells transduced with recombinant human TRPC3 or TRPC6, GSK-1702934A activated the TRPC3 and TRPC6 current with EC50 of 0.08 mM and 0.44 mM respectively. In the rat cardiomyocyte-like cell line H9C2 GSK-1702934A (1mM) activated TRPC6-like current and was completely blocked by GSK-417651A. It transiently increased the perfusion pressure of isolated rat heart retrogradely perfused via aortic cannulation at 1mM.1 Induces pro-arrhythmic and inotropic effects in TRPC3-overexpressing monocytes.2
References/Citations:
1) Xu et al. (2013) Characterization of Small Molecule TRPC3 and TRPC6 Agonists and Antagonists; Proceedings of the Biophysical Soc., 104(2) 454a
2) Doleschal et al. (2015) TRPC3 contributes to regulation of cardiac contractility and arrhythmogenesis by dynamic interaction with NCX1.; Cardiovasc. Res., 106 163
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
GSK1702934A (924377-85-5) is a TRPC3 activator. In whole-cell patch-clamp experiments in HEK293 cells transduced with recombinant human TRPC3 or TRPC6, GSK-1702934A activated the TRPC3 and TRPC6 current with EC50 of 0.08 mM and 0.44 mM respectively. In the rat cardiomyocyte-like cell line H9C2 GSK-1702934A (1mM) activated TRPC6-like current and was completely blocked by GSK-417651A. It transiently increased the perfusion pressure of isolated rat heart retrogradely perfused via aortic cannulation at 1mM.1 Induces pro-arrhythmic and inotropic effects in TRPC3-overexpressing monocytes.2
References/Citations:
1) Xu et al. (2013) Characterization of Small Molecule TRPC3 and TRPC6 Agonists and Antagonists; Proceedings of the Biophysical Soc., 104(2) 454a
2) Doleschal et al. (2015) TRPC3 contributes to regulation of cardiac contractility and arrhythmogenesis by dynamic interaction with NCX1.; Cardiovasc. Res., 106 163
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