GSK2636771 | Potent and selective inhibitor of PI3Kß
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $85.00 | ||
| 25 mg | $295.00 |
GSK2636771 (1372540-25-4) is a potent, selective (>1000-fold over α, 10-fold over δ, and >2000-fold over γ), and orally bioavailable inhibitor of PI3Kß (IC50 = 5.2 nM).1 Active in vitro against multiple types of PTEN-deficient cancer cells. GSK2636771 potently blocked migration and invasion of DU145 prostate cancer cells.2 GSK2636771 has also been identified as a GPR39 agonist.3
References/Citations:
- Mateo et al. (2017), A First-in-Human Study of GSK2636771, a Phosphoinositide 3 Kinase Beta-Selective Inhibitor, in Patients with Advanced Solid Tumors; Clin. Cancer Res. 23 5981
- Zhang et al. (2018), Phosphatidylinositol 3-kinase ß and δ isoforms play key roles in metastasis of prostate cancer DU145 cells; FASEB J. 32 5967
- Sato et al. (2016); Discovery and Characterization of Novel GPR39 Agonists Allosterically Modulated by Zinc, Mol. Pharmacol., 90 726
C22H22F3N3O3
>98% by HPLC
NMR: (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
GSK2636771 (1372540-25-4) is a potent, selective (>1000-fold over α, 10-fold over δ, and >2000-fold over γ), and orally bioavailable inhibitor of PI3Kß (IC50 = 5.2 nM).1 Active in vitro against multiple types of PTEN-deficient cancer cells. GSK2636771 potently blocked migration and invasion of DU145 prostate cancer cells.2 GSK2636771 has also been identified as a GPR39 agonist.3
References/Citations:
- Mateo et al. (2017), A First-in-Human Study of GSK2636771, a Phosphoinositide 3 Kinase Beta-Selective Inhibitor, in Patients with Advanced Solid Tumors; Clin. Cancer Res. 23 5981
- Zhang et al. (2018), Phosphatidylinositol 3-kinase ß and δ isoforms play key roles in metastasis of prostate cancer DU145 cells; FASEB J. 32 5967
- Sato et al. (2016); Discovery and Characterization of Novel GPR39 Agonists Allosterically Modulated by Zinc, Mol. Pharmacol., 90 726
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Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21
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Plymouth Meeting, PA USA
1-855-FOCUS21
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