GSK417651A | TRPC3/6 blocker

CAS:
736945-96-3
Catalog Number:
10-1434
Activity:
TRPC3/6 blocker
Chemical Name:
(3,4-Dihydroisoquinolin-2(1H)-yl)(2-((4-methoxyphenyl)amino)thiazol-4-yl)methanone
Molecular Weight:
365.46
Molecular Formula:
C20H19N3O2S
Solubility:
Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 15 mg/ml with warming).
Physical Properties:
Yellow solid
Purity:
99% by HPLC
NMR (Conforms)
Storage Temperature:
RT (des.)
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT

Available Options

size :PriceQuantity 
10 mg$100.00
50 mg$400.00

GSK417651A (736945-96-3) is a TRPC blocker. In whole-cell patch-clamp experiments in HEK293 cells transfected with recombinant human TRPC3 or TRPC6, GSK417651A blocked both TRPC3 and TRPC6 current with IC50 of ~0.04 μM.1 Combined pharmacological blockade of TRPC3 and TRPC6 inhibits cardiac hypertrophy.2 Cell permeable

References/Citations:

1) Xu et al. (2013), Characterization of small molecule TRPC3 and TRPC6 agonists and antagonists; Biophys. J., 104 Supp 1 454a
2)
Seo et al. (2014) Combined TRPC3 and TRPC6 blockade by selective small-molecule or genetic deletion inhibits pathological cardiac hypertrophy; Proc. Natl. Acad. Sci. USA, 111 1551

CAS:
736945-96-3
Catalog Number:
10-1434
Activity:
TRPC3/6 blocker
Chemical Name:
(3,4-Dihydroisoquinolin-2(1H)-yl)(2-((4-methoxyphenyl)amino)thiazol-4-yl)methanone
Molecular Weight:
365.46
Molecular Formula:
C20H19N3O2S
Solubility:
Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 15 mg/ml with warming).
Physical Properties:
Yellow solid
Purity:
99% by HPLC
NMR (Conforms)
Storage Temperature:
RT (des.)
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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