GSK583 | RIP2 kinase inhibitor

CAS:
1346547-00-9
Catalog Number:
10-4761
Activity:
RIP2 kinase inhibitor
Chemical Name:
6-tert-Butylsulfonyl-N-(5-fluoro-1H-indazol-3-yl)quinoline-4-amine
Molecular Weight:
398.45
Molecular Formula:
C20H19FN4O2S
Solubility:
Soluble in DMSO (up to at least 25 mg/ml).
Physical Properties:
Pale yellow solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Shipping Code:
RT

Available Options

Size:PriceQuantity 
10 mg$40.00
50 mg$150.00

GSK583 (1346547-00-9) is a highly selective and potent inhibitor of RIP2 kinase, IC50 = 5 nM human and IC50 = 2 nM rat.1 It also potently inhibits isolated RIP3 kinase (IC50 = 5 nM) but is inactive against RIP3 in cellular assays due to a very low KM,ATP. GSK583 blocks NOD2 signaling by interfering with XIAP-RIP2 binding resulting in decreased cytokine and chemokine production.1,2

References/Citations:

1) Haile et al. (2016), The Identification and Pharmacological Characterization of 6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinoline-4-amine; J. Med. Chem., 59 4867
2) Goncharov et al. (2018), Disruption of XIAP-RIP2 Association Blocks NOD2-Mediated Inflammatory Signaling; Mol. Cell, 69 551

CAS:
1346547-00-9
Catalog Number:
10-4761
Activity:
RIP2 kinase inhibitor
Chemical Name:
6-tert-Butylsulfonyl-N-(5-fluoro-1H-indazol-3-yl)quinoline-4-amine
Molecular Weight:
398.45
Molecular Formula:
C20H19FN4O2S
Solubility:
Soluble in DMSO (up to at least 25 mg/ml).
Physical Properties:
Pale yellow solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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