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GSK583 | RIP2 kinase inhibitor

GSK583 (1346547-00-9) is a highly selective and potent inhibitor of RIP2 kinase, IC50 = 5 nM human and IC50 = 2 nM rat.1 It also potently inhibits isolated RIP3 kinase (IC50 = 5 nM) but is inactive against RIP3 in cellular assays due to a very low KM,ATP. GSK583 blocks NOD2 signaling by interfering with XIAP-RIP2 binding resulting in decreased cytokine and chemokine production.1,2

 

References/Citations
1) Haile et al. (2016), The Identification and Pharmacological Characterization of 6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinoline-4-amine; J. Med. Chem., 59 4867
2) Goncharov et al. (2018), Disruption of XIAP-RIP2 Association Blocks NOD2-Mediated Inflammatory Signaling; Mol. Cell, 69 551

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Catalog#  10-4761-0005

$40.00
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Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
1346547-00-9
Catalog Number:
10-4761
Activity:
RIP2 kinase inhibitor
Chemical Name:
6-tert-Butylsulfonyl-N-(5-fluoro-1H-indazol-3-yl)quinoline-4-amine
Molecular Weight:
398.45
Molecular Formula:
C20H19FN4O2S
Solubility:
Soluble in DMSO (up to at least 25 mg/ml).
Physical Properties:
Pale yellow solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20° (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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