GSK620 | BD2 selective BET inhibitor
Available Options
| Size | Price | Quantity | |
|---|---|---|---|
| 5mg | $60.00 | ||
| 25mg | $225.00 |
GSK620 (2088410-46-0) is a BET inhibitor 220-fold more selective for BD2 over BD1 (pIC50 BD2 = 7.1; BD1 = 4.8).1 It ameliorated collagen-induced arthritis in a rat model and imiquimod-induced psoriasis in a mouse model.2 GSK620 was also able to reduce hepatic fibrosis, steatosis, and inflammation in a mouse model of non-alcoholic steatohepatitis (NASH).
References/Citations:
- Seal et al. (2020), The Optimization of a Novel, Weak Bromo and Extra Terminal Domain (BET) Bromodomain Fragment Ligand to a Potent and Selective Second Bromodomain (BD2) Inhibitor; J. Med. Chem., 63 9093
- Gilan et al. (2020), Selective targeting of BD1 and BD2 of the BET proteins in cancer and immunoinflammation; Science, 368 387
C18H19N3O3
>98% HPLC
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
GSK620 (2088410-46-0) is a BET inhibitor 220-fold more selective for BD2 over BD1 (pIC50 BD2 = 7.1; BD1 = 4.8).1 It ameliorated collagen-induced arthritis in a rat model and imiquimod-induced psoriasis in a mouse model.2 GSK620 was also able to reduce hepatic fibrosis, steatosis, and inflammation in a mouse model of non-alcoholic steatohepatitis (NASH).
References/Citations:
- Seal et al. (2020), The Optimization of a Novel, Weak Bromo and Extra Terminal Domain (BET) Bromodomain Fragment Ligand to a Potent and Selective Second Bromodomain (BD2) Inhibitor; J. Med. Chem., 63 9093
- Gilan et al. (2020), Selective targeting of BD1 and BD2 of the BET proteins in cancer and immunoinflammation; Science, 368 387
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