GSK872 | Necroptosis inhibitor / RIP3 inhibitor

CAS:
1346546-69-7
Catalog Number:
10-4861
Activity:
Necroptosis inhibitor / RIP3 inhibitor
Chemical Name:
N-(6-Propan-2-ylsulfonylquinolin-4-yl)-1,3-benzothiazol-5-amine
Alternate Names:
GSK2399872A
Molecular Weight:
383.49
Molecular Formula:
C19H17N3O2S2
Solubility:
Soluble in DMSO (up to at least 25 mg/ml)
Physical Properties:
Off-White or pale yellow solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Available Options

Size:PriceQuantity 
5 mg$60.00
25 mg$225.00

GSK 872 (CAS 1346546-69-7) is a potent (IC50 = 1.8nM domain binding; IC50 = 1.3 nM kinase activity) and selective inhibitor of receptor interacting protein 3 (RIP3).1 It is able to prevent necroptosis, virus-induced necrosis, and TLR3-induced necrosis.1,2 GSK872 can induce Caspase8-mediated apoptosis at higher concentrations (e.g.3 µM).2

References/Citations:

1) Kaiser et al. (2013) Toll-like receptor 3-mediated necrosis via TRIF, RIP3, and MLKL; J. Biol. Chem. 288 31279
2) Mandal et al. (2014) RIP3 induces apoptosis independent of pro-necrotic kinase activity; Mol. Cell 56 481

CAS:
1346546-69-7
Catalog Number:
10-4861
Activity:
Necroptosis inhibitor / RIP3 inhibitor
Chemical Name:
N-(6-Propan-2-ylsulfonylquinolin-4-yl)-1,3-benzothiazol-5-amine
Alternate Names:
GSK2399872A
Molecular Weight:
383.49
Molecular Formula:
C19H17N3O2S2
Solubility:
Soluble in DMSO (up to at least 25 mg/ml)
Physical Properties:
Off-White or pale yellow solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Safety Data Sheet:

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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