Gue1654 | OXE-R biased antagonist
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $60.00 | ||
| 25 mg | $240.00 |
Gue1654 (397290-30-1) is a biased antagonist for the oxoeicosanoid receptor 1 (OXE-R, GPR170)1, the receptor for 5-Oxo-ETE, a proinflammatory eicosanoid2. It selectively inhibits Gβγ but not Gαi signaling upon activation of the Gαi-βγ heterotrimer by OXE-R.1,3 Gue1654 alleviated coronary artery ligation-induced ischemic myocardial injury in a mouse model.4
References/Citations:
- Blatermann et al. (2012), A biased ligand for OXE-R uncouples Gα and Gßγ signaling within a heterotrimer; Nat. Chem. Biol., 8 631
- Powell and Rokach (2013), The eosinophil chemoattractant 5-oxo-ETE and the OXE receptor; Prog. Lipid Res., 52 651
- Konya et al. (2014), A biased non-Gαi OXE-R antagonist demonstrates that Gαi protein subunit is not directly involved in neutrophil, eosinophil, and monocyte activation by 5-oxo-ETE; J. Immunol., 192 4774
- Lai et al. (2021), Oxoeicosanoid receptor inhibition alleviates acute myocardial infarction though activation of BCAT1; Basic Res. Cardiol., 116 3
C23H17N3OS3
>98% TLC
NMR: (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Gue1654 (397290-30-1) is a biased antagonist for the oxoeicosanoid receptor 1 (OXE-R, GPR170)1, the receptor for 5-Oxo-ETE, a proinflammatory eicosanoid2. It selectively inhibits Gβγ but not Gαi signaling upon activation of the Gαi-βγ heterotrimer by OXE-R.1,3 Gue1654 alleviated coronary artery ligation-induced ischemic myocardial injury in a mouse model.4
References/Citations:
- Blatermann et al. (2012), A biased ligand for OXE-R uncouples Gα and Gßγ signaling within a heterotrimer; Nat. Chem. Biol., 8 631
- Powell and Rokach (2013), The eosinophil chemoattractant 5-oxo-ETE and the OXE receptor; Prog. Lipid Res., 52 651
- Konya et al. (2014), A biased non-Gαi OXE-R antagonist demonstrates that Gαi protein subunit is not directly involved in neutrophil, eosinophil, and monocyte activation by 5-oxo-ETE; J. Immunol., 192 4774
- Lai et al. (2021), Oxoeicosanoid receptor inhibition alleviates acute myocardial infarction though activation of BCAT1; Basic Res. Cardiol., 116 3
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