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GW-501516 | PPAR delta agonist

GW-501516 (317318-70-0) is a potent and selective PPARδ (NR1C2) agonist, EC50=1.2 nM and 1000-fold selective over other PPAR subtypes.1  Induces apolipoprotein A1-mediated cholesterol efflux in vitro.1 Improves hematopoietic stem cell maintenance.2 Prevents downregulation of AMPK caused by a high-fat diet in liver and increases fatty acid oxidation.3 Upregulates human Sirt1 via Sp1 activation.4 Along with exercise, GW-501516 synergistically increases running endurance.5


1) Oliver et al. (2001), A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport; Proc. Natl. Acad. Sci. USA, 98 5306
2) Ito et al. (2012), A PML-PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance; Nat. Med., 18 1350
3) Barroso et al. (2011), The PPARβ/δ activator GW501516 prevents the down-regulation of AMPK caused by a high-fat diet in liver and amplifies the PGC-1α-Lipin 1-PPARα pathway leading to increased fatty acid oxidation. Endocrinology, 152 1848
4) Okazaki et al. (2010), PPAR beta/delta regulates the human SIRT1 gene transcription via Sp1; Endocr. J., 57 403
5) Narkar et al. (2008), AMPK and PPARdelta agonists are exercise mimetics; Cell, 134 405

Focus Biomolecules cell signaling reagent supplier, chemical structure of GW-501516 | PPAR delta agonist | CAS 317318-70-0

Catalog#  10-1542-0005

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Catalog Number:
PPAR delta agonist
Chemical Name:
2-[2-Methyl-4-[[[4-methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazoyl]methyl]thio]phenoxy]acetic acid
Molecular Weight:
Molecular Formula:
Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 20 mg/ml)
Physical Properties:
Off-white solid
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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