GW1100 | GPR40 antagonist
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 5 mg | $50.00 | ||
| 25 mg | $170.00 |
GW1100 (306974-70-9) is a selective antagonist of GPR40. GW1100 inhibits GRP40-mediated Ca2+ increases stimulated by GW9508 (Cat.# 10-1108) or linoleic acid (pIC50 = 5.99 for either agonist).1 The effects of GPR40 activation on insulin secretion in cells are also blocked by the addition of GW1100. GW1100 does not influence calcium mobilization mediated by GPR120.
References/Citations:
1) Brisco et al. (2006), Pharmacological regulation of insulin secretion in MIN6 cells through fatty acid receptor GPR40: identification of agonist and antagonist molecules; Br. J. Pharmacol., 148 619
2) Nagatake et al. (2018), The 17,18-Epoxytetraenoic acid-G protein-coupled receptor 40 axis ameliorates contact hypersensitivity by inhibiting neutrophil mobility in mice and cynomolgus macaques; J. Allergy Clin. Immunol., 142 470 [Focus Biomolecules Citation]
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
GW1100 (306974-70-9) is a selective antagonist of GPR40. GW1100 inhibits GRP40-mediated Ca2+ increases stimulated by GW9508 (Cat.# 10-1108) or linoleic acid (pIC50 = 5.99 for either agonist).1 The effects of GPR40 activation on insulin secretion in cells are also blocked by the addition of GW1100. GW1100 does not influence calcium mobilization mediated by GPR120.
References/Citations:
1) Brisco et al. (2006), Pharmacological regulation of insulin secretion in MIN6 cells through fatty acid receptor GPR40: identification of agonist and antagonist molecules; Br. J. Pharmacol., 148 619
2) Nagatake et al. (2018), The 17,18-Epoxytetraenoic acid-G protein-coupled receptor 40 axis ameliorates contact hypersensitivity by inhibiting neutrophil mobility in mice and cynomolgus macaques; J. Allergy Clin. Immunol., 142 470 [Focus Biomolecules Citation]
Related products
-
Amlexanox | TBK1 inhibitor / Antidiabetic
From $40.00CAS:68302-57-8Catalog Number:10-1435Activity:TBK1 inhibitor / AntidiabeticChemical Name:2-Amino-7-(1-methylethyl)-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic acidMolecular Weight:298.29Molecular Formula:C16H14N2O4Solubility:Soluble in DMSO (up to 60 mg/ml).Physical Properties:White solidPurity:98%
NMR (Conforms)Storage Temperature:RTStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.Shipping Code:RT -
Andrographolide | Induces mitochondrial-mediated apoptosis
From $34.00CAS:5508-58-7Catalog Number:10-1173Activity:Induces mitochondrial-mediated apoptosisMolecular Weight:350.45Molecular Formula:C20H30O6Solubility:Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 8 mg/ml).Physical Properties:Off-white solidPurity:98%
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 2 years from date of purchsae as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.Shipping Code:RT -
Glyburide | K-ATP channel blocker
From $30.00CAS:10238-21-8Catalog Number:10-1325Activity:K-ATP channel blockerAlternate Names:GlibenclamideChemical Name:5-Chloro-N-[2-[4-[[[(cyclohexylamino)carbonyl]amino]suphonyl]phenyl]ethyl]-2-methoxybenzamideMolecular Weight:494.01Molecular Formula:C23H28ClN3O5SSolubility:Soluble in DMSO (up to 45 mg/ml) or in Ethanol (up to 2 mg/ml with warming).Physical Properties:White solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.Shipping Code:RT
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
