GW3965 HCl | LXR agonist
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $55.00 | ||
| 25 mg | $150.00 |
GW3965 (405911-17-3) is a potent and selective LXR agonist, activating human LXRα and β in cell-based reporter gene assays (EC50=190 and 30 nM respectively).1 Since LXR is a master regulator of cholesterol and fatty acid metabolism, GW3965 exerts a variety of effects including antiatherosclerotic2, antiinflammatory3 as well as antinociceptive4 and alteration of fat tissue distribution5. Orally active.
References/Citations:
- Collins et al. (2002), Identification of a nonsteroidal liver X receptor agonist through parallel array synthesis of tertiary amines; J.Med.Chem. 45 1963
- Blaschke et al. (2006), A nuclear receptor corepressor-dependent pathway mediates suppression of cytokine-induced C-reactive protein gene expression by liver X receptor; Nature 99 e88
- Schulman et al. (2017), Liver X Receptors Link Lipid Metabolism and Inflammation; FEBS Lett. 591 2978
- Hullugundi et al. (2024), Cholesterol-dependent LXR transcription factor activity represses pronociceptive effects of estrogen in sensory neurons and pain induced by myelin basic protein fragments; Brain Behav. Immun. Health 38 100757
- Archer et al. (2013), LXR activation by GW3965 alters fat tissue distribution and adipose tissue inflammation in ob/ob female mice; J. Lipid Res. 54 1300
C33H31ClF3NO3·HCl
>98% HPLC
NMR: (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
GW3965 (405911-17-3) is a potent and selective LXR agonist, activating human LXRα and β in cell-based reporter gene assays (EC50=190 and 30 nM respectively).1 Since LXR is a master regulator of cholesterol and fatty acid metabolism, GW3965 exerts a variety of effects including antiatherosclerotic2, antiinflammatory3 as well as antinociceptive4 and alteration of fat tissue distribution5. Orally active.
References/Citations:
- Collins et al. (2002), Identification of a nonsteroidal liver X receptor agonist through parallel array synthesis of tertiary amines; J.Med.Chem. 45 1963
- Blaschke et al. (2006), A nuclear receptor corepressor-dependent pathway mediates suppression of cytokine-induced C-reactive protein gene expression by liver X receptor; Nature 99 e88
- Schulman et al. (2017), Liver X Receptors Link Lipid Metabolism and Inflammation; FEBS Lett. 591 2978
- Hullugundi et al. (2024), Cholesterol-dependent LXR transcription factor activity represses pronociceptive effects of estrogen in sensory neurons and pain induced by myelin basic protein fragments; Brain Behav. Immun. Health 38 100757
- Archer et al. (2013), LXR activation by GW3965 alters fat tissue distribution and adipose tissue inflammation in ob/ob female mice; J. Lipid Res. 54 1300
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
