H-151 | STING Antagonist
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 10 mg | $65.00 | ||
| 50 mg | $240.00 |
H-151 (941987-60-6) is an inhibitor of the signaling molecule STING in mouse and human cells. It covalently binds to Cys91 of STING preventing activation via blockade of palmitoylation at Cys91. It reduced systemic cytokine response in mice treated with the STING agonist 10-carboxymethyl-9-acridanone and showed efficacy in Trex-/- mice.
References/Citations:
1) Haag et al. (2018), Targeting STING with covalent small-molecule inhibitors; Nature 559 269
2) Lee et al. (2019), STING restricts oHSV Replication and Spread in Resistant MPNSYs but Is Dispensable for Basal IFN-Stimulated Gene Upregulation; Mol. Ther. Oncolytics 15 91 [FOCUS Citation]
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
H-151 (941987-60-6) is an inhibitor of the signaling molecule STING in mouse and human cells. It covalently binds to Cys91 of STING preventing activation via blockade of palmitoylation at Cys91. It reduced systemic cytokine response in mice treated with the STING agonist 10-carboxymethyl-9-acridanone and showed efficacy in Trex-/- mice.
References/Citations:
1) Haag et al. (2018), Targeting STING with covalent small-molecule inhibitors; Nature 559 269
2) Lee et al. (2019), STING restricts oHSV Replication and Spread in Resistant MPNSYs but Is Dispensable for Basal IFN-Stimulated Gene Upregulation; Mol. Ther. Oncolytics 15 91 [FOCUS Citation]
Related products
-
AAL-993 | VEGFR inhibitor
From $75.00CAS:269390-77-4Catalog Number:10-1034Activity:VEGFR inhibitorChemical Name:2-[(4-Pyridyl)methyl]amino-N-[3-(trifluoromethyl)phenyl]benzamideMolecular Weight:371.36Molecular Formula:C20H16F3N3OSolubility:Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 15 mg/ml).Physical Properties:Pale yellow solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.Shipping Code:RT -
AG-490 | JAK2 inhibitor
From $50.00CAS:133550-30-8Catalog Number:10-1091Activity:JAK2 inhibitorChemical Name:(E)-2-Cyano-3-(3,4-dihydrophenyl)-N-(phenylmethyl)-2-propenamideMolecular Weight:294.31Molecular Formula:C17H14N2O3Solubility:Soluble in DMSO (up to 25 mg/ml), in DMF (up to 40 mg/ml), or in Ethanol (up to 10 mg/ml).Physical Properties:Tan solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO, DMF, or ethanol may be stored at -20°C for up to 1 month.Shipping Code:RT -
MK-571 | Cys LT1 antagonist
From $60.00CAS:115104-28-4Catalog Number:10-1039Activity:Cys LT1 antagonistAlternate Names:L-660711Chemical Name:5-(3-(2-(7-Chloroquinolin-2-yl)ethenyl)phenyl)-8-dimethylcarbamyl-4,6-dithiaoctanoic acidMolecular Weight:515.09Molecular Formula:C26H27ClN2O3S2Solubility:Soluble in DMSO (up to 50 mg/ml).Physical Properties:Yellow solidPurity:95% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.Shipping Code:RT
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
