H-89 2HCl | PKA inhibitor
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 5 mg | $50.00 | ||
| 25 mg | $180.00 |
H-89 (130964-39-5) is a commonly used inhibitor of protein kinase A (PKA IC50 = 140 nM). Inhibits a variety of other kinases including S6K1 (IC50 = 80 nM), MSK1 (120 nM), ROCK II (270 nM), PKBα (2.6 µM), PKD, PRK2, RSK1 and 2, SGK, AMPK, CHK1 and MAPKAP-K1b (2.8 µM).1,2
References/Citations:
1) Lochner and Moolman (2006), The many faces of H89: a review; Cardiovasc. Drugs, 24 261
2) Bain et al. (2007), The selectivity of protein kinase inhibitors: a further update; Biochem.J. 408(Pt3) 297
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
H-89 (130964-39-5) is a commonly used inhibitor of protein kinase A (PKA IC50 = 140 nM). Inhibits a variety of other kinases including S6K1 (IC50 = 80 nM), MSK1 (120 nM), ROCK II (270 nM), PKBα (2.6 µM), PKD, PRK2, RSK1 and 2, SGK, AMPK, CHK1 and MAPKAP-K1b (2.8 µM).1,2
References/Citations:
1) Lochner and Moolman (2006), The many faces of H89: a review; Cardiovasc. Drugs, 24 261
2) Bain et al. (2007), The selectivity of protein kinase inhibitors: a further update; Biochem.J. 408(Pt3) 297
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