HA-100·2HCl | Multi-kinase inhibitor
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $50.00 | ||
| 25 mg | $200.00 |
HA-100·2HCl (85568-24-6) inhibits the following kinases PKG (IC50=4 mM), PKA (IC50=8 mM), PKC (IC50=12 mM).1 Increases human fibroblast reprogramming efficiency with PD0325901, CHIR99021, A83-01 and hLIF.2 Improves single cell survival and supports high cloning efficiency in human pluripotent stem cells.3
References/Citations:
- Hagiwara et al. (1987), Selective modulation of calcium-dependent myosin phosphorylation by novel protein kinase inhibitors, isoquinolinesulfonamide derivatives; Pharmacol., 32 7
- Yu et al. (2011), Efficient feeder-free episomal reprogramming with small molecules; PLoS One, 6(3) e17557
- Chen et al. (2011), Chemically defined conditions for human iPSC derivation and culture; Nature Methods, 8 424
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
HA-100·2HCl (85568-24-6) inhibits the following kinases PKG (IC50=4 mM), PKA (IC50=8 mM), PKC (IC50=12 mM).1 Increases human fibroblast reprogramming efficiency with PD0325901, CHIR99021, A83-01 and hLIF.2 Improves single cell survival and supports high cloning efficiency in human pluripotent stem cells.3
References/Citations:
- Hagiwara et al. (1987), Selective modulation of calcium-dependent myosin phosphorylation by novel protein kinase inhibitors, isoquinolinesulfonamide derivatives; Pharmacol., 32 7
- Yu et al. (2011), Efficient feeder-free episomal reprogramming with small molecules; PLoS One, 6(3) e17557
- Chen et al. (2011), Chemically defined conditions for human iPSC derivation and culture; Nature Methods, 8 424
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