HC-067047 | TRPV4 blocker
NMR (Conforms)
Available Options
| size : | Price | Quantity | |
|---|---|---|---|
| 5 mg | $58.00 | ||
| 25 mg | $230.00 |
HC-067047 (883031-03-6) is a potent reversible and selective TRPV4 blocker. Active at mouse, human and rat TRPV4, IC50 = 17, 48 and 133 nM respectively. Also inhibits the endogenous TRPV4-mediated response to 4α-PDH (IC50 = 22 nM). Selective for TRPV4 over TRPV1, TRPV2, TRPV3 and TRPM8 channels.1 Increases functional bladder capacity and reduces micturition frequency in mice and rats with cystitis.1 Inhibits brain edema in middle cerebral artery occlusion mice.2 HC-067047 induces an increase in core body temperature accompanied by increased oxygen consumption in Wistar rats.3 Active in vivo.
References/Citations:
1) Everaerts et al. (2010), Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis; Proc. Natl. Acad. Sci. USA, 107 19084
2) Jie et al. (2015), Blockage of transient receptor potential vanilloid 4 inhibits brain edema in middle cerebral artery occlusion mice; Front. Cell. Neurosci., 9 141
3) Vizin et al. (2015), TRPV4 activates autonomic and behavioural warmth-defence responses in Wistar rats; Acta Physiol. (Oxf.), 214 275
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
HC-067047 (883031-03-6) is a potent reversible and selective TRPV4 blocker. Active at mouse, human and rat TRPV4, IC50 = 17, 48 and 133 nM respectively. Also inhibits the endogenous TRPV4-mediated response to 4α-PDH (IC50 = 22 nM). Selective for TRPV4 over TRPV1, TRPV2, TRPV3 and TRPM8 channels.1 Increases functional bladder capacity and reduces micturition frequency in mice and rats with cystitis.1 Inhibits brain edema in middle cerebral artery occlusion mice.2 HC-067047 induces an increase in core body temperature accompanied by increased oxygen consumption in Wistar rats.3 Active in vivo.
References/Citations:
1) Everaerts et al. (2010), Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis; Proc. Natl. Acad. Sci. USA, 107 19084
2) Jie et al. (2015), Blockage of transient receptor potential vanilloid 4 inhibits brain edema in middle cerebral artery occlusion mice; Front. Cell. Neurosci., 9 141
3) Vizin et al. (2015), TRPV4 activates autonomic and behavioural warmth-defence responses in Wistar rats; Acta Physiol. (Oxf.), 214 275
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Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21
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1-855-FOCUS21
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