HC-258 | Covalent TEAD inhibitor
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $70.00 | ||
| 25 mg | $225.00 |
HC-258 is a covalent inhibitor of TEAD (transcriptional enhanced associate domain), an important component of the Hippo pathway. It was able to reduce gene expression levels of CTGF, CYR61, AXL, and NF2 in MDA-MB-231 breast cancer cells. HC-258 also reduced MDA-MB-231 cell migration.
References/Citations:
- Fnaiche et al. (2023), Development of HC-258, a Covalent Acrylamide TEAD Inhibitor That Reduces Gene Expression and Cell Migration; ACS Med. Chem. Lett. 14 1746
C20H24N2O2
>98% TLC
NMR: (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
HC-258 is a covalent inhibitor of TEAD (transcriptional enhanced associate domain), an important component of the Hippo pathway. It was able to reduce gene expression levels of CTGF, CYR61, AXL, and NF2 in MDA-MB-231 breast cancer cells. HC-258 also reduced MDA-MB-231 cell migration.
References/Citations:
- Fnaiche et al. (2023), Development of HC-258, a Covalent Acrylamide TEAD Inhibitor That Reduces Gene Expression and Cell Migration; ACS Med. Chem. Lett. 14 1746
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