Herbimycin A | HSP90 Inhibitor

CAS:
70563-58-5
Catalog Number:
10-2567
Activity:
HSP90 Inhibitor
Chemical Name:
(15R)-17-Demethoxy-15 methoxy-11-O-methyl-geldanamycin
Molecular Weight:
574.68
Molecular Formula:
C30H42N2O9
Solubility:
Soluble in DMSO (up to 6 mg/ml).
Physical Properties:
Yellow lyophilized solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT

Available Options

Size :PriceQuantity 
100 µg$90.00
1 mg$400.00

Herbimycin A (70563-58-5) is an ansamycin antibiotic. Inhibits HSP90 and associated client proteins including v-Src, Bcr-Abl, Raf-1 and ErbB2.1,2 Herbimycin A reverts tyrosine kinase-induced oncogenic transformation without direct inhibition of phosphorylation activity.1 Inhibits angiogenesis in a rat retinopathy model.3

References/Citations:

1) Whitesell et al. (1994), Inhibition of heat shock protein HSP-90-pp60vsrc heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation; Proc. Natl. Acad. Sci. USA, 91 8324
2) Blagosklonny et al. (2002), Hsp-90-associated oncoproteins: multiple targets of geldanamycin and it’s analogs; Leukemia, 16 455
3) GW McCollum et al. (2004), Herbimycin A inhibits angiogenic activity in endothelial cells and reduces neovascularization in a rat model of retinopathy of prematurity; Exp. Eye Res., 78 987

CAS:
70563-58-5
Catalog Number:
10-2567
Activity:
HSP90 Inhibitor
Chemical Name:
(15R)-17-Demethoxy-15 methoxy-11-O-methyl-geldanamycin
Molecular Weight:
574.68
Molecular Formula:
C30H42N2O9
Solubility:
Soluble in DMSO (up to 6 mg/ml).
Physical Properties:
Yellow lyophilized solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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