Herboxidiene | Spliceosome inhibitor
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 200 ug | $85.00 | ||
| 1 mg | $340.00 |
Herboxidiene (142861-00-5) is a novel polyketide fermentation product produced by Streptomyces chromofuscus, originally discovered by screening for herbicidal activity. Potent and selective inhibitor of spliceosome subunit SF3b.2 Specifically targets SAP155, a subunit of SF3b responsible for pre-mRNA splicing.3 Displays anti-angiogenic activity via down-regulation of VEGFR-2 and HIF-1α.4 Spliceosome inhibitors have attracted enormous attention due to their potential use in cancer treatment.5
References/Citations:
1) Miller-Wideman et al. (1992), Herboxidiene, a new herbicidal substance from Streptomyces chromofuscus A7847. Taxonomy, fermentation, isolation, physio-chemical and biological properties; J. Antibiot. (Tokyo), 45 914
2) Gao et al. (2013), Comparison of splicing factor 3b inhibitors in human cells; Chembiochem, 14 49
3) Hasegawa et al. (2011), Identification of SAP155 as the target of GEX1A (Herboxidiene), an antitumor natural product; ACS Chem. Biol., 6 229
4) Jung et al. (2015), Antiangiogenic activity of herboxidiene via downregulation of vascular endothelial growth factor receptor-2 and hypoxia-inducible factor-1α; Arch. Pharm. Res., 38 1728
5) Martinez-Montiel et al. (2016), Microbial and Natural Metabolites That Inhibit Splicing: A Powerful Alternative for Cancer Treatment; Biomed. Res. Int., 2016 3681094
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Herboxidiene (142861-00-5) is a novel polyketide fermentation product produced by Streptomyces chromofuscus, originally discovered by screening for herbicidal activity. Potent and selective inhibitor of spliceosome subunit SF3b.2 Specifically targets SAP155, a subunit of SF3b responsible for pre-mRNA splicing.3 Displays anti-angiogenic activity via down-regulation of VEGFR-2 and HIF-1α.4 Spliceosome inhibitors have attracted enormous attention due to their potential use in cancer treatment.5
References/Citations:
1) Miller-Wideman et al. (1992), Herboxidiene, a new herbicidal substance from Streptomyces chromofuscus A7847. Taxonomy, fermentation, isolation, physio-chemical and biological properties; J. Antibiot. (Tokyo), 45 914
2) Gao et al. (2013), Comparison of splicing factor 3b inhibitors in human cells; Chembiochem, 14 49
3) Hasegawa et al. (2011), Identification of SAP155 as the target of GEX1A (Herboxidiene), an antitumor natural product; ACS Chem. Biol., 6 229
4) Jung et al. (2015), Antiangiogenic activity of herboxidiene via downregulation of vascular endothelial growth factor receptor-2 and hypoxia-inducible factor-1α; Arch. Pharm. Res., 38 1728
5) Martinez-Montiel et al. (2016), Microbial and Natural Metabolites That Inhibit Splicing: A Powerful Alternative for Cancer Treatment; Biomed. Res. Int., 2016 3681094
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