HIF-2α-I2 | HIF-2α antagonist
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 5 mg | $70.00 | ||
| 25 mg | $280.00 |
HIF-2α-I2 (1422955-31-4) is a potent and selective HIF-2α inhibitor, Kd=81 nM.1 Binds to the HIF-2α PAS-B domain2 and interferes with Hif-2α / ARNT heterodimerization reducing target gene expression in a cellular model1. Highly selective for HIF-2α displaying a >60-fold selectivity over HIF-1α.1,2
References/Citations:
1) Scheuermann et al. (2013), Allosteric inhibition of hypoxia inducible factor-2 with small molecules; Nat. Chem. Biol., 9 271
2) Masetti et al. (2014), Protein dynamics of the HIF-2α PAS-B domain upon heterodimerization and ligand binding; PLoS One, 9(4) e94986
3) Rodgers et al. (2013), Development of inhibitors of the PAS-B domain of the HIF-2α transcription factor; J. Med. Chem., 56 1739
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
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HIF-2α-I2 (1422955-31-4) is a potent and selective HIF-2α inhibitor, Kd=81 nM.1 Binds to the HIF-2α PAS-B domain2 and interferes with Hif-2α / ARNT heterodimerization reducing target gene expression in a cellular model1. Highly selective for HIF-2α displaying a >60-fold selectivity over HIF-1α.1,2
References/Citations:
1) Scheuermann et al. (2013), Allosteric inhibition of hypoxia inducible factor-2 with small molecules; Nat. Chem. Biol., 9 271
2) Masetti et al. (2014), Protein dynamics of the HIF-2α PAS-B domain upon heterodimerization and ligand binding; PLoS One, 9(4) e94986
3) Rodgers et al. (2013), Development of inhibitors of the PAS-B domain of the HIF-2α transcription factor; J. Med. Chem., 56 1739
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