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Hinokitiol | Iron Chelator antioxidant

Hinokitiol (499-44-5) is a potent metal chelator that induces differentiation and apoptosis in teratocarcinoma F9 cells.1 It acts as a reversible inhibitor of platelet-type 12-lipoxygenase (IC50 = 100 nM).2 Hinokitiol is reported to have strong antibacterial activity3, suppress cell growth and disrupt androgen receptor signaling4 and activate hypoxia-inducible factor5.

References/Citations
1) Ido et al (1999) Induction of apoptosis by hinokitiol, a potent iron chelator, in teratocarcinoma F9 cells is mediated through the activation of caspase-3; Cell Prolif., 32 63
2) Suzuki et al. (2000) Hinokitiol, a selective inhibitor of the platelet-type isozyme of arachidonate 12-lipoxygenase; Biochem. Biophys. Res. Commun., 275 885
3) Morita et al. (2007) The mechanism of the bactericidal activity of hinokitiol; Biocontrol Sci., 12 101
4) Liu and Yamauchi (2006) Hinokitiol, a metal chelator derived from natural plants, suppresses cell growth and disrupts androgen receptor signaling in prostate carcinoma cell lines; Biochem. Biophys. Res. Commun., 351 26
5) Lee et al. (2010) Hinokitiol activates the hypoxia-inducible factor (HIF) pathway through inhibition of HIF hydroxylases; Biochem. Biophys. Res. Commun., 396 370

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Focus Biomolecules supplier, chemical structure of Hinokitiol | Iron Chelator antioxidant | CAS 499-44-5

Catalog#  10-2211

$52.00
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CAS:
499-44-5
Catalog Number:
10-2211
Activity:
Iron Chelator antioxidant
Alternate Names:
β-Thujaplicin
Chemical Name:
2-Hydroxy-4-isopropyl-2,4,6-cycloheptatrien-1-one
Molecular Weight:
164.2
Molecular Formula:
C10H12O2
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
Physical Properties:
White solid
Purity:
>98%
Storage Temperature:
RT
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 4 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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