Homoharringtonine | Protein synthesis inhibitor
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $60.00 | ||
| 25 mg | $220.00 |
Homoharringtonine (26833-87-3) is a plant alkaloid, originally isolated from the Hainan plum yew, that binds to the large ribosomal subunit A-site, competing with aminoacyl-tRNA amino acid side chains, thereby inhibiting the initial elongation step of protein synthesis.1 It also binds to transcription factors NKRF (NF-κB repressing factor) and SP1, down-regulating the Myc pathway.2,3 Dramatically decreases global DNA 5-hydroxymethylcytosine levels via the SP1/TET1 axis.3 Induces apoptosis in tyrosine kinase inhibitor-resistant NSCLC cells4, and is a clinically useful agent for CML and AML5.
References/Citations:
- Gürel et al. (2009), U2504 determines the species specificity of the A-site cleft antibiotics: the structures of tiamulin, homoharringtonine, and bruceantin bound to the ribosome; J.Mol.Biol. 389 146
- Chen (2019), Homoharringtonine deregulates MYC transcriptional expression by directly binding NF-κB repressing factor; Proc. Natl. Acad. Sci. USA. 116 2220
- Li et al. (2020), Homoharringtonine exhibits potent anti-tumor effect and modulates DNA epigenome in acute myeloid leukemia by targeting SP1/TET1/5hmC; Haematologica 105 148
- Cao et al. (2015), Homoharringtonine induces apoptosis and inhibits STAT3 via IL-6/JAK1/STAT3 signal pathway in Gefitinib-resistant lung cancer cells; Sci. Rep. 5 8477
- Lu and Wang (2014), Homoharringtonine and omacetaxine for myeloid hematological malignancies; J. Hematol. Oncol. 7 2
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Homoharringtonine (26833-87-3) is a plant alkaloid, originally isolated from the Hainan plum yew, that binds to the large ribosomal subunit A-site, competing with aminoacyl-tRNA amino acid side chains, thereby inhibiting the initial elongation step of protein synthesis.1 It also binds to transcription factors NKRF (NF-κB repressing factor) and SP1, down-regulating the Myc pathway.2,3 Dramatically decreases global DNA 5-hydroxymethylcytosine levels via the SP1/TET1 axis.3 Induces apoptosis in tyrosine kinase inhibitor-resistant NSCLC cells4, and is a clinically useful agent for CML and AML5.
References/Citations:
- Gürel et al. (2009), U2504 determines the species specificity of the A-site cleft antibiotics: the structures of tiamulin, homoharringtonine, and bruceantin bound to the ribosome; J.Mol.Biol. 389 146
- Chen (2019), Homoharringtonine deregulates MYC transcriptional expression by directly binding NF-κB repressing factor; Proc. Natl. Acad. Sci. USA. 116 2220
- Li et al. (2020), Homoharringtonine exhibits potent anti-tumor effect and modulates DNA epigenome in acute myeloid leukemia by targeting SP1/TET1/5hmC; Haematologica 105 148
- Cao et al. (2015), Homoharringtonine induces apoptosis and inhibits STAT3 via IL-6/JAK1/STAT3 signal pathway in Gefitinib-resistant lung cancer cells; Sci. Rep. 5 8477
- Lu and Wang (2014), Homoharringtonine and omacetaxine for myeloid hematological malignancies; J. Hematol. Oncol. 7 2
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