Honokiol-DCA | TRAP1 Inhibitor

CAS:
 1620160-42-0
Catalog Number:
 10-3596
Honokiol-DCA Supplier | CAS 1620160-42-0 | Focus Biomolecules

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5mg$70.00
25mg$280.00

Honokiol-DCA (HDCA; 1620160-42-0), a synthetic bis-dichloroacetate ester of the natural product honokiol, is an allosteric inhibitor of the mitochondrial chaperone TRAP1.1 It binds to an allosteric site on TRAP1 leading to inhibition (IC50 ~8mM) and is selective over HSP90, unlike 17-AAG and radicicol which are nonselective. Inhibition of TRAP1 leads to upregulation of succinate dehydrogenase and the mitochondrial deacetylase SIRT3.  In neoplastic cells HDCA decreases proliferation, increases mitochondrial superoxide levels and abolishes tumorigenic growth.1 HDCA demonstrated in vivo activity against vemurafenib-resistant (LM36R) melanoma.2

References/Citations:

  1. Sanchez-Martin et al. (2021), Honokiol Bis-Dichloroacetate Is a Selective Allosteric Inhibitor of the Mitochondrial Chaperone TRAP1; Antioxid. Redox. Signal., 34 505
  2. Bonner et al. (2016), Honokiol bis-dichloroacetate (Honokiol DCA) demonstrates activity in vemurafenib-resistant melanoma in vivo; Oncotarget, 12857
CAS:
1620160-42-0
Catalog Number:
10-3596
Activity:
TRAP1 inhibitor
Chemical Names:
Honokiol bis-dichloroacetate
Alternate Name:
HDCA
Molecular Weight:
488.18
Molecular Formula:

C22H18Cl4O4

Solubility:
Soluble in DMSO (50 mg/ml)
Physical Properties:
Viscous oil
Purity:

>98% HPLC
NMR (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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