Honokiol | SIRT3 activator
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 10 mg | $55.00 | ||
| 50 mg | $220.00 |
Honokiol (35354-74-6) is a natural product that acts as a SIRT3 activator. It increases mitochondrial oxygen consumption and reduces ROS production in wild type but not SIRT3-KO cells.1 It reversed cardiac hypertrophy in mice1 and rescued myocardial and mitochondrial energetics in type 2 diabetic rats2. It was shown to increase SIRT3 expression in the hippocampus and attenuated surgery-induced memory loss, neuronal apoptosis, neuroinflammation and oxidative damage.3 It increases expression of adipocyte gene markers, gene-involved lipolysis and glucose transport and in general, promotes insulin sensitivity.4
References/Citations:
- Pillai et al. (2015), Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial SIRT3; Nat. Commun. 6 6656
- Kerr et al. (2020), Rescue of myocardial dysfunction in diabetes through the correction of mitochondrial hyperacetylation by honokiol; JCI Insight 5 e140326
- Ye et al. (2019), SIRT3 activator honokiol ameliorates surgery/anesthesia-induced cognitive decline in mice through anti-oxidative stress and anti-inflammatory in hippocampus; CNS Neurosci. 25 355
- Lee et al. (2022), Sirt3 Pharmacologically Promotes Insulin Sensitivity through PI3/AKT/mTOR and Their Downstream Pathway in Adipocytes; Int. J. Mol. Sci. 23 3740
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Honokiol (35354-74-6) is a natural product that acts as a SIRT3 activator. It increases mitochondrial oxygen consumption and reduces ROS production in wild type but not SIRT3-KO cells.1 It reversed cardiac hypertrophy in mice1 and rescued myocardial and mitochondrial energetics in type 2 diabetic rats2. It was shown to increase SIRT3 expression in the hippocampus and attenuated surgery-induced memory loss, neuronal apoptosis, neuroinflammation and oxidative damage.3 It increases expression of adipocyte gene markers, gene-involved lipolysis and glucose transport and in general, promotes insulin sensitivity.4
References/Citations:
- Pillai et al. (2015), Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial SIRT3; Nat. Commun. 6 6656
- Kerr et al. (2020), Rescue of myocardial dysfunction in diabetes through the correction of mitochondrial hyperacetylation by honokiol; JCI Insight 5 e140326
- Ye et al. (2019), SIRT3 activator honokiol ameliorates surgery/anesthesia-induced cognitive decline in mice through anti-oxidative stress and anti-inflammatory in hippocampus; CNS Neurosci. 25 355
- Lee et al. (2022), Sirt3 Pharmacologically Promotes Insulin Sensitivity through PI3/AKT/mTOR and Their Downstream Pathway in Adipocytes; Int. J. Mol. Sci. 23 3740
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