Honokiol | SIRT3 activator

Honokiol (35354-74-6) is a natural product that acts as a SIRT3 activator. It increases mitochondrial oxygen consumption and reduces ROS production in wild type but not SIRT3-KO cells.¹ It reversed cardiac hypertrophy in mice¹ and rescued myocardial and mitochondrial energetics in type 2 diabetic rats². It was shown to increase SIRT3 expression in the hippocampus and attenuated surgery-induced memory loss, neuronal apoptosis, neuroinflammation and oxidative damage.³ It increases expression of adipocyte gene markers, gene-involved lipolysis and glucose transport and in general, promotes insulin sensitivity.⁴

References/Citations:

1. Pillai et al. (2015), Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial SIRT3; Nat. Commun. 6 6656
2. Kerr et al. (2020), Rescue of myocardial dysfunction in diabetes through the correction of mitochondrial hyperacetylation by honokiol; JCI Insight 5 e140326
3. Ye et al. (2019), SIRT3 activator honokiol ameliorates surgery/anesthesia-induced cognitive decline in mice through anti-oxidative stress and anti-inflammatory in hippocampus; CNS Neurosci. 25 355
4. Lee et al. (2022), Sirt3 Pharmacologically Promotes Insulin Sensitivity through PI3/AKT/mTOR and Their Downstream Pathway in Adipocytes; Int. J. Mol. Sci. 23 3740