HPA | HDAC inhibitor
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 20 mg | $40.00 | ||
| 100 mg | $90.00 |
HPA (96017-59-3) is a histone deacetylase (HDAC) inhibitor, IC50=13 μM.1 More potent and robust than valproic acid at inducing histone hyperacetylation (600% at 50 μM), HSP70 induction and protection against glutamate excitotoxicity in cultured neurons.2 Cell permeable.
References/Citations:
1) Eikel et al. (2006), Teratogenic effects mediated by inhibition of histone deacetylases: evidence from quantitative structure activity relationships of 20 valproic acid derivatives; Chem. Res. Toxicol., 19 272
2) Leng et al. (2010), Potent neuroprotective effects of novel structural derivatives of valproic acid: potential roles of HDAC inhibition and HSP70 induction; Neurosci. Lett., 476 127
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
HPA (96017-59-3) is a histone deacetylase (HDAC) inhibitor, IC50=13 μM.1 More potent and robust than valproic acid at inducing histone hyperacetylation (600% at 50 μM), HSP70 induction and protection against glutamate excitotoxicity in cultured neurons.2 Cell permeable.
References/Citations:
1) Eikel et al. (2006), Teratogenic effects mediated by inhibition of histone deacetylases: evidence from quantitative structure activity relationships of 20 valproic acid derivatives; Chem. Res. Toxicol., 19 272
2) Leng et al. (2010), Potent neuroprotective effects of novel structural derivatives of valproic acid: potential roles of HDAC inhibition and HSP70 induction; Neurosci. Lett., 476 127
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