HPI-1 | Hedgehog pathway inhibitor
NMR (conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 5 mg | $75.00 | ||
| 25 mg | $265.00 |
HPI-1 (599150-20-6) is a Hedgehog pathway inhibitor acting downstream of Smo and independently of PKA, PI3K and MAPK. It can suppress Hh pathway activation induced by loss of Su(fu) or Gli overexpression. HPI-1 inhibits both endogenous and exogenous Gli1/Gli2 activity. IC50‘s range from 0.2 to 6 μM for various cell-based assays.
References/Citations:
1) Hyman 0et al. (2009) Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade; Proc. Natl. Acad. Sci.USA, 106 14132
NMR (conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
HPI-1 (599150-20-6) is a Hedgehog pathway inhibitor acting downstream of Smo and independently of PKA, PI3K and MAPK. It can suppress Hh pathway activation induced by loss of Su(fu) or Gli overexpression. HPI-1 inhibits both endogenous and exogenous Gli1/Gli2 activity. IC50‘s range from 0.2 to 6 μM for various cell-based assays.
References/Citations:
1) Hyman 0et al. (2009) Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade; Proc. Natl. Acad. Sci.USA, 106 14132
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