HTS01037 | FABP inhibitor

CAS:
682741-29-3
Catalog Number:
10-1453
Activity:
FABP inhibitor
Chemical Name:
4-[(3-Carboxy-1-oxo-2-propen-1-yl)amino]-[2,2’-bithiophene]-5-carboxylic acid, 5-methyl ester
Molecular Weight:
337.37
Molecular Formula:
C14H11NO5S2
Solubility:
Soluble in DMSO (up to 50 mg/ml)
Physical Properties:
Yellow solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT

Available Options

Size :PriceQuantity 
5 mg$60.00
25 mg$240.00

HTS01037 (682741-29-3) inhibits fatty acid binding proteins.  Inhibits lipolysis in 3T3-L1 adipocytes and reduces LPS-stimulated inflammation in cultured macrophages.  Acts as an antagonist of the protein-protein interaction between AFABP/aP2 and hormone sensitive lipase but does not activate PPARg in macrophages.1 Inhibits FABP-dependent and fatty acid-stimulated leukotriene C4 biosynthesis.2  Reduces intracellular free fatty acid levels, lowering macrophage inflammation and ER stress.3 Reduces LPS-stimulated IL-1b secretion in a mouse model.4 Inhibits VLDL-induced foam cell formation.5

References/Citations:

1) Hertzel et al. (2009), Identification and characterization of a small molecule inhibitor of Fatty Acid binding proteins; J. Med. Chem, 52 6024
2) Long et al. (2012), Fatty acids induce leukotriene C4 synthesis in macrophages in a fatty acid binding protein-dependent manner; Biochim. Biophys. Acta, 1831 1199
3) Xu et al. (2015), Uncoupling lipid metabolism from inflammation through fatty acid binding protein-dependent expression of USP2; Mol. Cell. Biol., 35 1055
4) Steen et al. (2016), FABP4/aP2 regulates macrophage redox signaling and inflammasome activation via control of UCP2; Mol. Cell. Biol., 37 e00282
5) Boss et al. (2015), FABP4 inhibition suppresses PPARgamma activity and VLDL-induced foam cell formation in IL-4-polarized human macrophages; Atherosclerosis, 240 424

CAS:
682741-29-3
Catalog Number:
10-1453
Activity:
FABP inhibitor
Chemical Name:
4-[(3-Carboxy-1-oxo-2-propen-1-yl)amino]-[2,2’-bithiophene]-5-carboxylic acid, 5-methyl ester
Molecular Weight:
337.37
Molecular Formula:
C14H11NO5S2
Solubility:
Soluble in DMSO (up to 50 mg/ml)
Physical Properties:
Yellow solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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