Huperzine A | Acetylcholinesterase Inhibitor
Available Options
| Size | Price | Quantity | |
|---|---|---|---|
| 5mg | $65.00 | ||
| 25mg | $265.00 |
Huperzine A (102518-79-6) is a nootropic alkaloid from the club moss Huperzia serrata that reversibly inhibits acetylcholinesterase (AChE, preferentially the tetrameric form, Ki = 7 nM)1, and antagonizes NMDA receptors (IC50 rat cerebral cortex = 126 µM)2. It is thought to have cognitive-enhancing properties, including amelioration of Alzheimer’s disease.3,4 Recently, it has also been shown to rescue ovarian function in rats5 as well as display analgesic activity in a rat spinal cord compression model6.
References\Citations:
- Zhao and Tang (2002), Effects of huperzine A on acetylcholinesterase isoforms in vitro: comparison with tacrine, donepezil, rivastigmine and physostigmine; Eur. J. Pharmacol., 455 101
- Zhang and Hu (2001), Huperzine A, a nootropic alkaloid, inhibits N-methyl-D-aspartate-induced current in rat dissociated hippocampal neurons; Neuroscience, 105 663
- Zangara (2003), The psychopharmacology of huperzine A: an alkaloid with cognitive enhancing and neuroprotective properties of interest in the treatment of Alzheimer’s disease; Pharmacol. Biochem. Behav., 75 675
- Qan et al. (2020), Dissolving microneedles for transdermal delivery of huperzine A for the treatment of Alzheimer’s disease; Drug Deliv., 27 1147
- Riquelme et al. (2020), Huperzine-A administration recovers rat ovary function after sympathetic stress; Neuroendocrinol., e12914
- Yu et al. (2013), Alleviation of chronic pain following rat spinal cord compression injury with multimodal actions of huperzine A; Proc. Natl. Acad. Sci. USA, 110 E746
C15H18N2O
>98% HPLC
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Huperzine A (102518-79-6) is a nootropic alkaloid from the club moss Huperzia serrata that reversibly inhibits acetylcholinesterase (AChE, preferentially the tetrameric form, Ki = 7 nM)1, and antagonizes NMDA receptors (IC50 rat cerebral cortex = 126 µM)2. It is thought to have cognitive-enhancing properties, including amelioration of Alzheimer’s disease.3,4 Recently, it has also been shown to rescue ovarian function in rats5 as well as display analgesic activity in a rat spinal cord compression model6.
References\Citations:
- Zhao and Tang (2002), Effects of huperzine A on acetylcholinesterase isoforms in vitro: comparison with tacrine, donepezil, rivastigmine and physostigmine; Eur. J. Pharmacol., 455 101
- Zhang and Hu (2001), Huperzine A, a nootropic alkaloid, inhibits N-methyl-D-aspartate-induced current in rat dissociated hippocampal neurons; Neuroscience, 105 663
- Zangara (2003), The psychopharmacology of huperzine A: an alkaloid with cognitive enhancing and neuroprotective properties of interest in the treatment of Alzheimer’s disease; Pharmacol. Biochem. Behav., 75 675
- Qan et al. (2020), Dissolving microneedles for transdermal delivery of huperzine A for the treatment of Alzheimer’s disease; Drug Deliv., 27 1147
- Riquelme et al. (2020), Huperzine-A administration recovers rat ovary function after sympathetic stress; Neuroendocrinol., e12914
- Yu et al. (2013), Alleviation of chronic pain following rat spinal cord compression injury with multimodal actions of huperzine A; Proc. Natl. Acad. Sci. USA, 110 E746
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