Hypothemycin | MEK inhibitor

CAS:
76958-67-3
Catalog Number:
10-2483
Activity:
MEK inhibitor
Source:
Natural product isolated from Phoma sp.
Molecular Weight:
378.37
Molecular Formula:
C19H22O8
Solubility:
Soluble in DMSO (up to 10 mg/ml)
Physical Properties:
White solid
Purity:
>96% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Available Options

Size :PriceQuantity 
1 mg$200.00

Hypothemycin (76958-67-3) is a potent and selective inhibitor of MEK.1-3 Acts via covalent binding to Cys residue.2 In cells, hypothemycin inhibits the MEK-ERK axis with sufficient selectivity to normalize transformed phenotypes3. Inhibits TNFα production in LPS-stimulated macrophages.4

References/Citations:

1) Zhou et al. (1999), Resorcylic acid lactones: naturally occurring potent and selective inhibitors of MEK; J. Antibiot., 52 1086
2) Schirmer et al. (2006), Targeted covalent inactivation of protein kinases by resorcylic acid lactone polyketides; Proc. Natl. Acad. Sci. USA, 103 4234
3) Fukazawa et al. (2010), The resorcylic acid lactone hypothemycin selectively inhibits the mitogen-activated protein kinase kinase-extracellular signal-regulated kinase pathway in cells; Biol. Pharm. Bull., 33 168
4) Park et al. (2015), Hypothemycin inhibits tumor necrosis factor-α production by tristetraprolin-dependent down-regulation of mRNA stability in lipopolysaccharide-stimulated macrophages; Int. Immunopharmacol., 29 863

CAS:
76958-67-3
Catalog Number:
10-2483
Activity:
MEK inhibitor
Source:
Natural product isolated from Phoma sp.
Molecular Weight:
378.37
Molecular Formula:
C19H22O8
Solubility:
Soluble in DMSO (up to 10 mg/ml)
Physical Properties:
White solid
Purity:
>96% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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