Iberdomide | Cereblon modulator/Molecular glue
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $75.00 | ||
| 25 mg | $250.00 |
Iberdomide (1323403-33-3) is a modulator of the cullin ring ligase 4-cereblon E3 ubiquitin ligase complex with higher affinity (IC50 = 60 nM) than lenalidomide and pomalidomide leading to more potent degradation of Ikaros (IKZF1; EC50 = 1 nM)) and Aiolos (IKZF3; EC50 = 0.5 nM).1 It is more specific for the cereblon complex and does not degrade GSPT1 or CK1α. It displays antitumor and immunostimulatory activity in lenalidomide- and pomalidomide-resistant multiple myeloma cells.2 Iberdomide has also shown efficacy in treating the autoimmune disease cutaneous lupus erythematosus (CLE).3 It was also shown to act as an HIV-1 latency reversal agent in in CD4+ T-cells.4
References/Citations:
- Matyskiela et al. (2018), A Cereblon Modulator (CC-220) with Improved Degradation of Ikaros and Aiolos; J. Med. Chem., 61 535
- Bjorkland et al. (2020), Iberdomide (CC-220) is a potent cereblon E3 ligase modulator with antitumor and immunostimulatory activities in lenalidomide- and pomalidomide-resistant multiple myeloma cells with dysregulated CRBN; Leukemia, 34 1197
- Sprow et al. (2022), Emerging Therapies in Cutaneous Lupus Erythematosus; Front. Med. (Lausanne), 9 968323
- Ne et al. (2022), Catchet-MS identifies IKZF1-targeting thalidomide analogues as novel HIV-1 latency reversal agents; Nucleic Acids Res., 50 5577
C25H27N3O5
>98% by HPLC
NMR: (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Iberdomide (1323403-33-3) is a modulator of the cullin ring ligase 4-cereblon E3 ubiquitin ligase complex with higher affinity (IC50 = 60 nM) than lenalidomide and pomalidomide leading to more potent degradation of Ikaros (IKZF1; EC50 = 1 nM)) and Aiolos (IKZF3; EC50 = 0.5 nM).1 It is more specific for the cereblon complex and does not degrade GSPT1 or CK1α. It displays antitumor and immunostimulatory activity in lenalidomide- and pomalidomide-resistant multiple myeloma cells.2 Iberdomide has also shown efficacy in treating the autoimmune disease cutaneous lupus erythematosus (CLE).3 It was also shown to act as an HIV-1 latency reversal agent in in CD4+ T-cells.4
References/Citations:
- Matyskiela et al. (2018), A Cereblon Modulator (CC-220) with Improved Degradation of Ikaros and Aiolos; J. Med. Chem., 61 535
- Bjorkland et al. (2020), Iberdomide (CC-220) is a potent cereblon E3 ligase modulator with antitumor and immunostimulatory activities in lenalidomide- and pomalidomide-resistant multiple myeloma cells with dysregulated CRBN; Leukemia, 34 1197
- Sprow et al. (2022), Emerging Therapies in Cutaneous Lupus Erythematosus; Front. Med. (Lausanne), 9 968323
- Ne et al. (2022), Catchet-MS identifies IKZF1-targeting thalidomide analogues as novel HIV-1 latency reversal agents; Nucleic Acids Res., 50 5577
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