Size: | Price | Quantity | |
---|---|---|---|
5 mg | $75.00 | ||
25 mg | $250.00 |
Iberdomide (1323403-33-3) is a modulator of the cullin ring ligase 4-cereblon E3 ubiquitin ligase complex with higher affinity (IC50 = 60 nM) than lenalidomide and pomalidomide leading to more potent degradation of Ikaros (IKZF1; EC50 = 1 nM)) and Aiolos (IKZF3; EC50 = 0.5 nM).1 It is more specific for the cereblon complex and does not degrade GSPT1 or CK1α. It displays antitumor and immunostimulatory activity in lenalidomide- and pomalidomide-resistant multiple myeloma cells.2 Iberdomide has also shown efficacy in treating the autoimmune disease cutaneous lupus erythematosus (CLE).3 It was also shown to act as an HIV-1 latency reversal agent in in CD4+ T-cells.4
References/Citations:
C25H27N3O5
>98% by HPLC
NMR: (Conforms)
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Iberdomide (1323403-33-3) is a modulator of the cullin ring ligase 4-cereblon E3 ubiquitin ligase complex with higher affinity (IC50 = 60 nM) than lenalidomide and pomalidomide leading to more potent degradation of Ikaros (IKZF1; EC50 = 1 nM)) and Aiolos (IKZF3; EC50 = 0.5 nM).1 It is more specific for the cereblon complex and does not degrade GSPT1 or CK1α. It displays antitumor and immunostimulatory activity in lenalidomide- and pomalidomide-resistant multiple myeloma cells.2 Iberdomide has also shown efficacy in treating the autoimmune disease cutaneous lupus erythematosus (CLE).3 It was also shown to act as an HIV-1 latency reversal agent in in CD4+ T-cells.4
References/Citations:
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