ICA-110381 | Kv7.2/7.3 activator

CAS:
325457-99-6
Catalog Number:
10-1467
Activity:
Kv7.2/7.3 activator
Chemical Name:
4-Chloro-N-(6-chloro-3-pyridinyl)benzamide
Molecular Weight:
267.12
Molecular Formula:
C12H8Cl2N2O
Solubility:
Soluble in DMSO (up to 26 mg/ml) or in Ethanol (up to 5 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT

Available Options

Size:PriceQuantity 
5 mg$50.00
25 mg$150.00

ICA-110381 (325457-99-6) is a KCNQ2/Q3 (Kv7.2/7.3) activator, EC50=0.38 μM (KCNQ1 IC50=15 μM).1 KCNQ3/Q5 heterodimers are not affected2. Potently dampens neuronal excitability and displays anticonvulsant activity in vivo.2

References/Citations:

1) Amato et al. (2011), N-Pyridyl and Pyrimidine Benzamides as KCNQ2/Q3 Potassium Channel Openers for the Treatment of Epilepsy; Sci. ACS Med. Chem. Lett., 2 481
2) Boehlen et al. (2013), The new KCNQ2 activator 4-Chlor-N-(6-chlor-pyridin-3-yl)benzamid displays anticonvulsant potential; Br. J. Pharmacol., 168 1182

CAS:
325457-99-6
Catalog Number:
10-1467
Activity:
Kv7.2/7.3 activator
Chemical Name:
4-Chloro-N-(6-chloro-3-pyridinyl)benzamide
Molecular Weight:
267.12
Molecular Formula:
C12H8Cl2N2O
Solubility:
Soluble in DMSO (up to 26 mg/ml) or in Ethanol (up to 5 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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