ICA-121431 | Selective Sodium channel blocker

CAS:
313254-51-2
Catalog Number:
10-4085
Activity:
Selective Nav1.1/1.3 inhibitor
Chemical Names:
2,2-Diphenyl-N-[4-(1,3-thiazol-2-ylsulfamoyl)phenyl]acetamide
Molecular Weight:
449.54
Molecular Formula:
C23H19N3O3S2
Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
Off-white to beige solid
Purity:
>98% TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Available Options

Size:PriceQuantity 
5 mg$50.00
25 mg$175.00
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ICA-121431 (313254-51-2) is a selective Nav1.1/1.3 inhibitor (hIC50s = 23 and 13 nM respectively; also selective for dog, monkey, and mouse, but not rat).1  It exclusively shifts voltage dependence to more negative voltages and accelerates entry into slow activation.2

References/Citations:

  1. McCormack et al. (2013), Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels; Proc. Natl. Acad. Sci. USA 110 E2724
  2. Ostenn et al. (2017), Pharmacology of the Nav1.1 domain IV voltage sensor reveals coupling between inactivation gating processes; Proc. Natl. Acad. Sci. USA 114 6836
CAS:
313254-51-2
Catalog Number:
10-4085
Activity:
Selective Nav1.1/1.3 inhibitor
Chemical Names:
2,2-Diphenyl-N-[4-(1,3-thiazol-2-ylsulfamoyl)phenyl]acetamide
Molecular Weight:
449.54
Molecular Formula:
C23H19N3O3S2
Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
Off-white to beige solid
Purity:
>98% TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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