ICG-001 | Wnt beta-catenin inhibitor

CAS:
847591-62-2
Catalog Number:
10-4378
Activity:
Wnt β-catenin inhibitor
Chemical Name:
(6S,9aS)-Hexahydro-6-[(4-hydroxypheny;)methyl]-8-(1-naphthalenylmethyl)-4,7-dioxo-N-(phenylmethyl)-2H- pyrazine[1,2-a]pyrimidine-1(6H)-carboxamide
Molecular Weight:
548.63
Molecular Formula:
C33H32N4O4
Solubility:
Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 25 mg/ml).
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Available Options

Size :PriceQuantity 
5 mg$65.00
25 mg$250.00
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ICG-001 (847591-62-2) inhibits TCF/β-catenin mediated transcription by specifically blocking β-catenin/CBP interaction.

References/Citations:

1) Emami et al. (2004), A small molecule inhibitor of β-catenin/CREB-binding protein transcription;  Proc. Natl. Acad. Sci. USA, 101 12682
2) Zhou et al. (2012), Interactions between β-catenin and transforming growth factor-β signaling pathways mediate epithelial-mesenchymal transition and are dependent on the transcription co-activator cAMP-response element-binding protein (CERB)-binding protein (CBP);  J. Biol. Chem., 287 7026

CAS:
847591-62-2
Catalog Number:
10-4378
Activity:
Wnt β-catenin inhibitor
Chemical Name:
(6S,9aS)-Hexahydro-6-[(4-hydroxypheny;)methyl]-8-(1-naphthalenylmethyl)-4,7-dioxo-N-(phenylmethyl)-2H- pyrazine[1,2-a]pyrimidine-1(6H)-carboxamide
Molecular Weight:
548.63
Molecular Formula:
C33H32N4O4
Solubility:
Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 25 mg/ml).
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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